阿魏酸钠联合氯沙坦治疗早期糖尿病肾脏疾病疗效的研究

目的探讨阿魏酸钠联合氯沙坦治疗早期糖尿病肾脏疾病的疗效。方法选取60例早期糖尿病肾病的患者,随机分为两组,各30例。对照组单用氯沙坦,观察组应用氯沙坦联合阿魏酸钠。1个月后比较两组尿白蛋白排泄率（UAER）、血清肌酐（Scr）、血内皮素-1（ET-1）以及尿β2微球蛋白（β2-MG）以及治疗前后差异。结果观察组UAER、Scr、ET-1及β2-MG和对照组治疗后比较,差异有统计学意义（P〈0.05）。观察组治疗后UAER、Scr、ET-1及β2-MG比治疗前显著下降,差异有统计学意义（P〈0.01、P〈0.05）;对照组治疗后UAER、Scr及ET-1比治疗前下降,β2-MG轻度升高,但差异均无统计学意义（P〉0.05）。两组治疗1个月后疗效比较,观察组显效15例,有效13例,无效2例,总有效率为93.33%。对照组显效13例,有效8例,无效9例,总有效率为70.00%,两组总有效率比较差异有统计学意义（P〈0.05）。结论阿魏酸钠联合氯沙坦治疗早期糖尿病肾脏疾病比单用氯沙坦更有效

Research of the curative effect on Sodium Ferulate combined with Losartan in the treatment of early diabetic nephropathy

Objective To investigate the curative effect of Sodium Ferulate combined with Losartan in the treatment of early diabetic nephropathy.Methods 60 cases of patients with early diabetic nephropathy were randomly divided into two groups,with 30 cases in each group.The control group was given single Losartan,and the observation group was given Losartan combined with Sodium Ferulate.After treatment for one month,the urinary albumin excretion rate(UAER),serum creatinine(Scr),endothelin-1(ET-1) and urinary β2 microglobulin(β2-MG) and the differences before and after therapy between the two groups were compared.Results Compared with control group,the UAER,Scr,ET-1 and β2-MG after treatment in the observation group were statistically significant(P < 0.05).The UAER,Scr,ET-1 and β2-MG after treatment in the observation group were markedly decreased,the differences were statistically significant(P < 0.01,P < 0.05).The UAER,Scr,ET-1 after treatment in the control group were decreased than before treatment,and β2-MG was slightly increased than before treatment,but the differences were not statistically significant(P > 0.05).Compared with the clinical effect after one month of the two groups,in observation group,there were 15 cases of excellent,13 cases of valid,2 cases of invalid and the total effective percentage was 93.33%;in control group,there were 13 cases of excellent,8 cases of valid,9 cases of invalid and the total effective percentage was 70.00%,there was statistically significant difference of the total effective percentage(P < 0.05).Conclusion Sodium Ferulate combined with Losartan on early diabetic nephropathy has better effects than Losartan solely.