| 血清IL-6水平在神经胶质瘤预后中的意义 |
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| 引用本文： | 朱萧,王芳,卢敏莹,潘东晓,胡树珍,申鸿卓,罗凯,贺智敏,王金龙.血清IL-6水平在神经胶质瘤预后中的意义[J].解剖科学进展,2011,17(4):317-320. |
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| 作者姓名： | 朱萧 王芳 卢敏莹 潘东晓 胡树珍 申鸿卓 罗凯 贺智敏 王金龙 |
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| 作者单位： | 1. 广州医学院附属肿瘤医院肿瘤研究所,广东广州,510095
2. 中山大学肿瘤防治中心,华南肿瘤学国家重点实验室,广东广州510060 |
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| 基金项目： | 国家自然科学基金资助项目，广州医学院博士科研启动基金 |
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| 摘 要： | 目的探讨血清白细胞介素-6在神经胶质瘤患者预后中的潜在意义。方法收集手术前182位神经胶质瘤病人和49位正常供血者的血清样本。使用酶联免疫吸附试验测定白细胞介素-6水平。与血清癌胚抗原(CEA)、甲胎球蛋白(AFP)和C-反应蛋白(CRP)水平比较,评估白介素-6的临床意义。结果神经胶质瘤患者血清白介素-6水平明显高于健康对照组。血清白介素-6水平与癌胚抗原密切相关,但是与AFP和CRP关系不大。患者血清IL-6水平与患者TNM分期显著相关。此外,高血清的IL-6水平与神经胶质瘤的不良预后相关联。结论血清IL-6是神经胶质瘤的预后因子。
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| 关 键 词： | 白介素-6 神经胶质瘤 病人 预后 |
Prognosis significance of serum IL-6 level in glioma patients |
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| ZHU Xiao,WANG Fang,LU Min-ying,PAN Dong-xiao,HU Shu-zhen,SHEN Hong-zhuo,LUO Kai,HE Zhi-min,WANG Jing-long.Prognosis significance of serum IL-6 level in glioma patients[J].Progress of Anatomical Sciences,2011,17(4):317-320. |
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| Authors: | ZHU Xiao WANG Fang LU Min-ying PAN Dong-xiao HU Shu-zhen SHEN Hong-zhuo LUO Kai HE Zhi-min WANG Jing-long |
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| Affiliation: | ZHU Xiao1,WANG Fang2,LU Min-ying1,PAN Dong-xiao1,HU Shu-zhen1,SHEN Hong-zhuo1,LUO Kai1,HE Zhi-min1,WANG Jing-long1 (1.Cancer Institute,Affiliated Tumor Hospital,Guangzhou Medical University,Guangzhou 510095 China,2.State Key Laboratory of Oncology in South China,Cancer Center,Sun Yat-sen University,Guangzhou 510060 China) |
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| Abstract: | Objective To study the prognosis significance of interleukin-6 (IL-6) level in serum of glioma patients.Methods Preoperative serum samples from 182 patients with glioma and 49 normal healthy volunteers were used to determine IL-6 levels by enzyme-linked immunosorbent assay (ELISA).The clinical significance of serum IL-6 levels was evaluated and compared with serum carcinoembryonic antigen (CEA) levels,alpha-fetoglobulin (AFP) and serum C-reactive protein (CRP) levels in these patients.Results The serum leve... |
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| Keywords: | IL-6 glioma patient prognosis |
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