Hypoxia-inducible factor 1α regulates branching morphogenesis during kidney development |
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| Authors: | Kenji Tsuji Shinji KitamuraHirofumi Makino |
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| Affiliation: | Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan |
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| Abstract: | The kidneys are exposed to hypoxic conditions during development. Hypoxia-inducible factor (HIF), an important mediator of the response to hypoxia, is believed to have an important role in development. However, the relationship between HIF and branching morphogenesis has not been elucidated clearly. |
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| Keywords: | HIF-1α Kidney development Hypoxia Ureteric bud branching |
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