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| 肝素酶及Ki-67在非小细胞肺癌中的表达及临床意义 | |
| 引用本文： | 宋作庆,徐萧洪,韦森,陈军,刘懿,李昕,赵洪林,邱小明,周乃康. 肝素酶及Ki-67在非小细胞肺癌中的表达及临床意义[J]. 中国肺癌杂志, 2009, 12(7). DOI: 10.3779/j.issn.1009-3419.2009.07.008 |
| 作者姓名： | 宋作庆 徐萧洪 韦森 陈军 刘懿 李昕 赵洪林 邱小明 周乃康 |
| 作者单位： | 1. 天津医科大学总医院天津市肺癌研究所肺部肿瘤外科,天津,300052 2. 天津医科大学总医院天津市肺癌研究所ICU,天津,300052 3. 解放军总医院胸外科,北京,100853 |
| 摘 要： | 背景与目的 已有的研究表明,肝素酶与Ki-67抗原与肺癌的发生和转移有关,本研究通过检测非小细胞肺癌(Non-small cell lung cancer,NSCLC)组织中肝素酶(heparanase,Hpa)和Ki-67的表达,以探讨他们的临床意义及相互关系.方法 采用免疫组化方法 (S-ABC法和S-P法)检测70例NSCLC和20例同期良性病变肺组织中肝素酶和Ki-67的表达.结果 肝素酶和Ki-67的阳性表达率分别为72.9%和85.7%,而正常肺组织中两者均无表达;肝素酶表达水平与患者TNM分期及淋巴结转移有关(P=0.044,P=0.001);Ki-67的表达水平与原发肿瘤大小、组织学类型、癌细胞分化程度、淋巴结转移及TNM分期有关(P<0.05);肝素酶和Ki-67的表达差异无统计学意义(P=0.323).结论 肝素酶和Ki-67参与了肺癌的发生和发展,并与预后相关;而肝素酶和Ki-67的表达无相关性,两者可能通过不同的机制参与了肿瘤的发生和发展. |
| 关 键 词： | 肺肿瘤 肝素酶 免疫组化 |
Expression and Clinical Significance of Heparanase and Ki-67 in Non-small Cell Lung Cancer |
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| Zuoqing SONG,Xiaohong XU,Sen WEI,Jun CHEN,Yi LIU,Xin LI,Honglin ZHAO,Xiaoming QIU,Naikang ZHOU. Expression and Clinical Significance of Heparanase and Ki-67 in Non-small Cell Lung Cancer[J]. Chinese journal of lung cancer, 2009, 12(7). DOI: 10.3779/j.issn.1009-3419.2009.07.008 | |
| Authors: | Zuoqing SONG Xiaohong XU Sen WEI Jun CHEN Yi LIU Xin LI Honglin ZHAO Xiaoming QIU Naikang ZHOU |
| Affiliation: | Zuoqing SONG1,Xiaohong XU2,Sen WEI1,Jun CHEN1,Yi LIU1,Xin LI1,Honglin ZHAO1,Xiaoming QIU1,Naikang ZHOU3 1Department of Lung Cancer Surgery,Tianjin Lung Cancer Insititute,Tianjin Medical University General Hospital,Tianjin 300052,China,2Intensive Care Unite,3Department of Thoracic Surgery,PLA General Hospital,Beijing 100853 |
| Abstract: | Background and objective It has been proven that heparanase and Ki-67 had relationship with occurrence and metastasis in lung cancer.The aim of this work was to investigate the expressions of heparanase and Ki-67 and to explore their clinical significance and mutual relations in non-small cell lung cancer(NSCLC).Methods Immunohistochemical method was used to detect the heparanase and Ki-67expression in the routinely paraffin-embedded sections of surgical specimen of 70 cases with NSCLC and 20 ones with norm... |
| Keywords: | Ki-67 Lung neoplasms Heparanase Ki-67 Immunohistochemistry |
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