人白细胞抗原—DRB1等位基因与中国西部泡状棘球蚴病易感性？…

目的 了解人白细胞抗原（ＨＬＡ）＝ＤＲＢ１等位基因与泡球蚴病相关性，阐明泡球蚴病的免疫学发病机制，探寻 球蚴病的易感基因或抗病基因提供线索。方法 应用ＰＣＲ／ＳＳＲ技术，对中国西部甘肃省漳县、岷县泡球蚴病高流行区４个 的３５例口才１０４例正常人九进行了ＨＬＡ－ＤＲＢ１基因型分析。结果 且ＨＬＡ－ＤＲＢ１＊０４０Ｘ基因频率为２６％（１８／７０），正常对照组籽１０％（２０／２０８）（ＲＲ＝４．４５，Ｘ

Association of HLA DRB1 allele and the susceptibility to alveolar echinococcosis in the west of China

OBJECTIVE: To investigat the association of HLA-DRB1 alleles and the susceptibility to alveolar echinococcosis (AE). METHODS: Thirty-five patients with AE in the high prevalence areas in the west of China were investigated for HLA-DRB1 gene by PCR/SSP technique. The results were compared with 104 normal healthy peoples. RESULTS: Frequency of HLA-DRB1 * 040x was 26% in patient group, which was significantly higher than in control group (9.62%), with a relative risk (RR) of 4.45 (chi(2) = 13.67, P < 0.01), and with an etiological fraction of 0.20. Frequency of HLA-DRB1 * 0701 allele was decreased in patient group (patient 2.86%, control 13.94%; chi(2) = 6.67, P < 0.05), with preventable fraction of 0.30. While the frequencies of other DRB1 alleles were not significantly different. CONCLUSION: Susceptibility to AE is strongly associated with the HLA-DRB1 * 040x allele. The high prevalence of human AE in this region was associated with genetic factor. HLA-DRB1 * 0701 geners resistant to Echinococcus multilocularis metacestode infection.