Kelch样环氧氯丙烷相关蛋白-1-核因子E2相关因子2/抗氧化反应元件抗氧化应激通路在多发性硬化中作用的研究进展

多发性硬化(MS)是一种慢性炎症性疾病,主要是由T淋巴细胞引起,可使中枢神经系统产生氧化应激反应,导致脱髓鞘等病理改变。Kelch样环氧氯丙烷相关蛋白-1 (Keap1)-核因子E2相关因子2 (Nrf2)/抗氧化反应元件(ARE)抗氧化应激通路是体内最重要的内源性抗氧化应激通路,激活该通路可启动下游解毒酶、抗氧化蛋白,参与清除氧自由基,维持细胞内氧化还原系统平衡,从而对神经退行性疾病起保护作用。通过药物或各种康复治疗手段激活该Keap1-Nrf2/ARE通路,减轻MS疾病进展的作用及未来MS治疗靶点是目前研究热点。

Role of Kelch-like ECH-associated Protein-1-Nuclear Factor Erythroid 2-related Factor-2/Antioxidant Responsive Element Signal Pathway for Multiple Sclerosis(review)

Multiple sclerosis(MS)is a chronic inflammatory disease,mainly due to the activation of the T cells,which makes oxidative stress reaction in brain and leads to demyelination finally.Kelch-like ECH-associated protein-1(Keap1)-nuclear factor erythroid 2-related factor-2(Nrf2)/antioxidant responsive element(ARE)signal pathway is one of the most important endogenous antioxidant pathways,which promotes the expression of detoxification enzymes and antioxidant protein to eliminate oxygen free radicals and balance intracellular redox system.Activation of the Keap1-Nrf2/ARE may delay the progression of MS by drugs or rehabilitation.