金花清感颗粒联合布地奈德、沙丁胺醇、异丙托溴铵三联雾化吸入疗法在儿童肺炎支原体肺炎中的应用观察

目的 分析金花清感颗粒联合布地奈德、沙丁胺醇、异丙托溴铵三联雾化吸入治疗儿童肺炎支原体肺炎（MPP）的效果。方法 前瞻性选取2022年2月—2023年2月常熟市第二人民医院收治的114例MPP患儿为研究对象，按照随机数字表法分为对照组、研究组，每组57例。对照组给予布地奈德、沙丁胺醇、异丙托溴铵三联雾化吸入治疗，研究组在对照组基础上给予金花清感颗粒，连续治疗10 d评估效果。比较两组症状改善情况、肺功能、临床疗效、气道重塑指标、炎症因子、T淋巴细胞亚群及药物不良反应发生情况。结果 研究组发热消退时间、咳嗽消失时间、肺部啰音消失时间均短于对照组（P <0.05）。研究组治疗前后的达峰时间比、达峰容积比、呼吸频率的差值均高于对照组（P <0.05）。研究组总有效率高于对照组（P <0.05）。研究组治疗前后的气道壁厚度/外径比值、气道面积/总横截面积比值的差值均高于对照组（P <0.05）。研究组治疗前后的超敏C反应蛋白、白细胞介素-6、肿瘤坏死因子-α的差值均高于对照组（P <0.05）。研究组治疗前后的CD4+、CD8+、CD4+/CD8+的差值均高于对照...

Observation on the application of Jinhua Qinggan granules combined with budesonide, salbutamol, ipratropium bromide triple nebulization inhalation therapy in children with mycoplasma pneumonia

Objective To analyze the efficacy of Jinhua Qinggan Granules combined with budesonide, salbutamol, and ipratropium bromide triple nebulization inhalation therapy in children with Mycoplasma pneumonia (MPP).Methods A prospective study was conducted on 114 children with MPP admitted to the Second People''s Hospital of Changshu City from February 2022 to February 2023. They were divided into a control group and a study group, with 57 cases in each group, according to a random number table. The control group received budesonide, salbutamol, and ipratropium bromide triple nebulization inhalation therapy, while the study group received Jinhua Qinggan Granules in addition to the treatment received by the control group. The treatment lasted for 10 days, and the effects were evaluated. The improvement of symptoms, lung function, clinical efficacy, airway remodeling indicators, inflammatory factors, T lymphocyte subsets, and occurrence of adverse drug reactions were compared between the two groups.Results The study group had shorter fever subsidence time, cough disappearance time, and disappearance time of lung rales compared to the control group (P < 0.05). The differences in peak time ratio, peak volume ratio, and respiratory rate between before and after treatment were higher in the study group than in the control group (P < 0.05). The total effective rate in the study group was higher than that in the control group (P < 0.05). The differences in airway wall thickness/outer diameter ratio, airway area/total cross-sectional area ratio before and after treatment were higher in the study group than in the control group (P < 0.05). The differences in high-sensitivity C-reactive protein, interleukin-6, and tumor necrosis factor-alpha before and after treatment were higher in the study group than in the control group (P < 0.05). The differences in CD4⁺, CD8⁺, and CD4⁺/CD8⁺ before and after treatment were higher in the study group than in the control group (P < 0.05). There was no statistically significant difference in the occurrence of total adverse reactions between the two groups (P > 0.05).Conclusion Jinhua Qinggan Granules combined with budesonide, salbutamol, and ipratropium bromide triple nebulization inhalation therapy has significant efficacy in treating children with MPP, improving lung function, resisting airway remodeling, suppressing inflammatory reactions, improving T lymphocyte subsets, and exhibiting good safety.