dl—3—n—丁基苯酞对右大脑右中动脉阻断大鼠纹状体脑血流的影响

观察ｄｌ－３－ｎ－丁基苯酞（ＮＢＰ）对右大离右中动脉阻断（ＲＭＣＡＯ）大鼠缺血区局部脑血流（ｒＣＢＦ）的影响。方法：氢清除法动态监测ＲＭＣＡＯ大鼠ｒＣＢＦ变化。结果：ＲＭＣＡＯ后１０ｍｉｎ ｉｐ ＮＢＰ（５，１０，２０ｍｇ·ｋｇ＾－１）可明显增加ｒＣＢＦ（与溶剂对照组相比Ｐ〈０．０１），４０ｍｉｎ给药有类似作用但作用较弱（与给药前相比Ｐ〈０．０５），６０ｍｉｎ给药不能增加ｒＣＢＦ（与给药前相比Ｐ〉

Effects of dl-3-n-butylphthalide on regional cerebral blood flow in right middle cerebral artery occlusion rats.

AIM: To study the effect of dl-3-n-butylphthalide (NBP) on regional cerebral blood flow (rCBF) in forcal cerebral ischemia rats. METHODS: In chloral hydrate-anesthetized rat, the proximal portion of right middle cerebral artery (RMCA) was occluded, and H2 needle electrode was implanted in right striatum. rCBF was monitored in striatum using hydrogen clearance method. RESULTS: Ten min after RMCA occlusion (RMCAO), NBP (5, 10, 20 mg.kg-1 i.p.) markedly increased rCBF to striatum (P < 0.01). When NBP was given i.p. 40 min after RMCAO, the increasing effect on rCBF was also observed (P < 0.05). However, when NBP was injected i.p. 60 min after RMCAO, the increasing effect of NBP on rCBF was not found. In NBP-pretreated (i.p. 40 min before RMCAO) group, rCBF in striatum measured at different time points of 30, 60, 90, 120, 150, and 180 min after RMCAO were increased by 97%, 107%, 136%, 211%, 173%, and 317%, respectively, compared with the percentages of vehicle group. The potency of the effect of Nim (0.5 mg.kg-1 i.p.) was similar to that of NBP (10 mg.kg-1 i.p.). CONCLUSION: NBP pre-treatment or post-treatment markedly enhanced the rCBF to striatum in RMCAO rats.