The challenge of long-term stability for nucleic acid-based electrochemical sensors |
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| Authors: | Alexander Shaver Netzahualcóyotl Arroyo-Currás |
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| Affiliation: | 1. Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA;2. Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, 21218, USA;3. Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, 21218, USA |
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| Abstract: | Nucleic acid-based electrochemical sensors are a versatile technology enabling affinity-based detection of a great variety of molecular targets, regardless of inherent electrochemical activity or enzymatic reactivity. Additionally, their modular interface and ease of fabrication enable rapid prototyping and sensor development. However, the technology has inhibiting limitations in terms of long-term stability that have precluded translation into clinically valuable platforms like continuous molecular monitors. In this opinion, we discuss published methods to address various aspects of sensor stability, including thiol-based monolayers and anti-biofouling capabilities. We hope the highlighted works will motivate the field to develop innovative strategies for extending the long-term operational life of nucleic acid-based electrochemical sensors. |
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| Keywords: | Electrochemical sensors Nucleic acids Thiol monolayers Biofouling Long-term stability |
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