| 高效液相色谱法测定妇科千金分散片中穿心莲内酯和脱水穿心莲内酯含量 |
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| 引用本文： | 许宁,廖亚琴,李喜平.高效液相色谱法测定妇科千金分散片中穿心莲内酯和脱水穿心莲内酯含量[J].中国药业,2012(22):59-60. |
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| 作者姓名： | 许宁 廖亚琴 李喜平 |
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| 作者单位： | 浙江省衢州市人民医院;浙江省衢州市衢江区人民医院;浙江天昊药业有限公司 |
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| 摘 要： | 目的建立妇科千金分散片中穿心莲内醋和脱水穿心莲内醋含量的测定方法。方法采用Shimadzu VP-ODS柱（150 mm×4.6 mm,5μm）,以甲醇-水（52∶48）为流动相,穿心莲内酯检测波长为225 nm,脱水穿心莲内检测波长为254 nm。结果样品中穿心莲内酯与脱水穿心莲内酯进样量分别在0.200 4～2.040 0μg与0.117 2～0.702 4μg范围内与相应峰面积呈良好线性关系。结论该法操作简便、快速、准确、灵敏、结果准确,可作为妇科千金分散片质量控制的有效方法。
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| 关 键 词： | 高效液相色谱法 妇科千金分散片 穿心莲内酯 脱水穿心莲内酯 含量测定 |
Content Determination of Andrographolide and Dehyandrographolide in Fukeqianjin Dispersible Tablets by HPLC |
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| Xu Ning,Liao Yaqin,Li Xiping.Content Determination of Andrographolide and Dehyandrographolide in Fukeqianjin Dispersible Tablets by HPLC[J].China Pharmaceuticals,2012(22):59-60. |
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| Authors: | Xu Ning Liao Yaqin Li Xiping |
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| Affiliation: | 1.Quzhou Municipal People’ s Hospital,Quzhou,Zhejiang,China 324000;2.Qujiang District People’ s Hospital,Quzhou,Zhejiang,China 324000;3.Zhejiang Tianhao Pharmaceutical Co.,Ltd.,Quzhou,Zhejiang,China 324002) |
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| Abstract: | Objective To establish a method for the determination of andrographolide and dehyandrographolide in Fukeqianjin Dispersible Tablets.Methods By adopting the method of HPLC,the Shimadzu VP-ODS column（150 mm × 4.6 mm,5 μm） was used with the mobile phase of methanol-water（52：48）.The detective wavelengths were 225 nm and 254 nm respectively.Results The linear ranges of andrographolide and dehydroandrographolide were 0.200 4-2.040 0 μg and 0.117 2-0.702 4 μg respectively.Conclusion This methods is simple,rapid and sensitive with accurate detect results,which can be used as the effective method for controlling the quality of Fukeqianjin Dispersible Tablets. |
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| Keywords: | HPLC Fukeqianjin Dispersible Tablets andrographolide dehydroandr ographolide content determination |
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