| 高效液相色谱法测定布洛芬片中布洛芬含量 |
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| 引用本文： | 郑静,陈德俊. 高效液相色谱法测定布洛芬片中布洛芬含量[J]. 中国药业, 2007, 16(23): 27-28 |
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| 作者姓名： | 郑静 陈德俊 |
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| 作者单位： | 山东省药品检验所,山东,济南,250012 |
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| 摘 要： | 目的建立高效液相色谱法测定布洛芬片中布洛芬的含量。方法色谱柱为Zorbax—Extend C18柱（150mm×4．6mm，5μm），甲醇-0．01m01／L磷酸二氢钾一磷酸（700：300：0．1）为流动相，流速为1．0mL／min，检测波长为263nm。结果布洛芬质量浓度线性范围是100～800μg／mL，r=0．9999，其低、中、高3个量级的平均回收率分别为99．4％，98．8％，100．2％，RSD分别为0．8％，0．7％，1．0％。结论该法测定布洛芬中布洛芬的含量，结果可靠、简便、准确。
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| 关 键 词： | 高效液相色谱法 布洛芬 含量测定 |
| 文章编号： | 1006-4931(2007)23-0027-02 |
| 修稿时间： | 2007-03-05 |
Determination of Ibuprofen in Ibuprofen Tablet by HPLC |
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| Zheng Jing,Chen Dejun. Determination of Ibuprofen in Ibuprofen Tablet by HPLC[J]. China Pharmaceuticals, 2007, 16(23): 27-28 |
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| Authors: | Zheng Jing Chen Dejun |
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| Affiliation: | Zheng Jing, Chen Dejun ( Shandong Provincal Institute for Drug Control, Jinan, Shandong, China 250012) |
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| Abstract: | Objective To establish a method for the determination of ibuprofen in ibuprofen tablet. Methods The chromatographic column of Zorbax-Extend C18 （150 mm×4.6 mm, 5 μm）.The mobile phase was consisted of methanol-0.01 mol/L potassium dihydrogen phosphate solution-phosphoric acid （700： 300：0. 1）,and the flow rate was 1.0 mL/min, the UV detector wavelength was 263 nm. Results The linearity of ibuprofen was obtained separately over the range of 100- 800 μg/mL （r = 0. 999 9）. The average recovery rates of ibuprofen were 99. 4%, 98. 8% and 100. 2% with corresponding RSD of 0. 8%, 0. 7% and 1.0%. Conclusion The HPLC method is simple and reliable for the simultaneous determination of ibuprofen in ibuprofen tablets. |
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| Keywords: | HPLC ibuprofen content determination. |
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