| 3,5-双三氟甲基苯甲酸的合成研究 |
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| 引用本文： | 张宪军,南震. 3,5-双三氟甲基苯甲酸的合成研究[J]. 化工中间体, 2006, 0(5): 17-18,14 |
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| 作者姓名： | 张宪军 南震 |
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| 作者单位： | 大连化工研究设计院,大连,116023 |
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| 摘 要： | 3,5-双三氟甲基苯甲酸[CAS:725-89-3]的合成是先通过1,3-二溴-5,5-二甲基乙内酰脲,与1,3-双三氟甲基苯生成3,5-双三氟甲基溴苯,收率98%,选择性99%.然后由3,5-双三氟甲基溴苯作原料来合成3,5-双三氟甲基苯甲酸,收率72%以上.本文讨论了不同反应摩尔比,反应温度等条件,并得到最优化条件.
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| 关 键 词： | 3,5-双三氟甲基溴苯 1,3-二溴-5,5-二甲基乙内酰脲 3,5-双三氟甲基苯甲酸 |
| 文章编号： | 1006-253x（2006）05-0017-2 |
synthesis of 3,5-bis-(trifluoromethyl)-benzoic acid |
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| Zhang Xianjun,Nan Zhen. synthesis of 3,5-bis-(trifluoromethyl)-benzoic acid[J]. , 2006, 0(5): 17-18,14 |
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| Authors: | Zhang Xianjun Nan Zhen |
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| Abstract: | The 1,Br-3,5-bis-(trifluormethyl)-benzene was prep. Using of 1,3-diBromo-5.5-dimethyl-imidazolidine-2,4-dione and 1,3-bis-(trifluoromethyl)-benzene as material, was synthesized in sulphuric acid.The yield of 98%,the select of 99% 3,5-bis-(trifluoromethyl)-benzoic acid[CAS:725-89-3] was prep,using of The 1,Br-3,5-bis-(trifluormethyl)-benzene as material, was synthesized in sulphuric acid the yield of 72%.The influene factors such as molar ratio of material reactiom tempereture catalyst and time was studied. The best reaction was obtained. |
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| Keywords: | 1 Br-3 5-bis-(trifluormethyl)-benzene 1 3-diBromo-5.5-dimethyl-imidazolidine-2 4-dione3 5-bis-(trifluoromethyl)-benzoic acid |
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