北京地区空气污染对中老年高血压患者血压的影响

目的探究北京地区空气污染对中老年高血压患者血压的影响。方法招募85例北京市年龄在45～85岁,身体活动能力良好的高血压常住居民。排除现患有其他严重心肺系统疾病、感染或变态反应性疾病者。从各研究对象居住地附近的环境空气监测站收集PM_2.5、PM₁₀、SO_2、NO_2、O_3和CO的浓度数据,持续时间为5 d。应用线性混合效应模型(单污染物模型、双污染物模型),探究6种空气污染物与血压的相关关系。结果在单污染物模型中,空气污染物除O_3外,其余5种污染物短期暴露使收缩压(SBP)水平升高(P<0.05);脉压(PP)随O_3暴露水平的增加而降低(P<0.05)、随SO_2的暴露而升高(P<0.05)。结论短期暴露于空气污染可导致中老年高血压患者收缩压、脉压水平的升高。

Impact of air pollution on blood pressure in middle-aged and elderly patients with hypertension in Beijing

Objective To investigate the associations of air pollution with blood pressure in middle and old-aged hypertensive patients in Beijing. Methods A total of 85 local residents of hypertension aged 45 to 85 years old and with good physical activity in Beijing was recruited. Exclude patients with other serious cardio-pulmonary diseases, infections, or allergic diseases. We checked the 24 hourly concentration of PM 2.5 , PM 10 , SO 2, NO 2, O 3 and CO from the nearest Beijing monitoring sites for 5 days. Linear mixed effect model with a random intercept for each participant to account the dependent repeated measures was used to estimate the associations between 6 air pollutants and blood pressure. Results In the single-pollutant model, short-term exposure to 6 pollutants except O 3 resulted in an increase in SBP( P <0.05). PP decreased with O 3 exposure( P <0.05)and increased with SO 2 exposure( P <0.05). Conclusions Short-term exposure to air pollution may significantly elevate the SBP and PP of hypertensive patients.