卵巢上皮性癌中HIF-1α表达及其与血管生成细胞增殖的关系

目的:探讨卵巢上皮性癌组织中缺氧诱导因子-1α(HIF-1α)表达及其与血管生成和细胞增殖的关系。方法:采用免疫组织化学法检测卵巢上皮性癌组织中HIF-1α表达,并检测其微血管密度(CD34标记)和癌细胞增殖指数(PCNA标记)。结果:卵巢上皮性癌组织中的HIF-1α、微血管密度(MVD)、PCNA指数明显高于良性肿瘤;HIF-1α表达与临床分期相关,与病理分级和组织学分类无相关性;HIF-1α表达与MVD及PCNA之间存在显著相关性。结论:HIF-1α过度表达可能参与卵巢癌的发生发展,且与卵巢癌新生血管的形成和细胞增殖有密切关系,可作为反映卵巢癌生物学行为的有效指标。

Expression of HIF-1α and its relationship with neovascularization and tumor cell proliferation in epithelial ovarian cancer

Objective To investigate the e xpression of HIF-1αand its relationship with neovascul arization and tumor ce ll proliferation in epithelial ovarian cancer.Methods The expression of HIF- 1α,microvascular density(MVD)labelled by CD34protein and prolife ration i ndexes of cancer cells labelled by proliferating cell nuclear an tigen(PCNA)pr otein were examined in 76cases by i mmunohistochemistry.Results The expressio n of HIF-1α,MVD and PCNA indexes in epithelial ovarian cancer was hig her th an that in ovarian...