注射用加替沙星与酚磺乙胺注射液的配伍稳定性考察

目的:考察注射用加替沙星与酚磺乙胺注射液在0.9%氯化钠注射液和5%葡萄糖注射液中配伍的稳定性。方法:在室温((20±1)℃)下,观察8h内配伍液在0.9%氯化钠注射液和5%葡萄糖注射液中的外观,测定pH值及考察紫外光谱的变化,并用紫外双波长分光光度法测定加替沙星和酚磺乙胺的含量。结果:2药配伍后,8h内的pH值及外观均无明显变化,在0.9%氯化钠注射液中8h内以及在5%葡萄糖注射液中6h内,配伍液的含量无明显变化。结论:加替沙星与酚磺乙胺注射液在0.9%氯化钠注射液和5%葡萄糖注射液中配伍稳定。

Compatible Stability of Gatifloxacin for Injection with Etamsylate Injection

OBJECTIVE ：To study the compatibility of gatifloxacin for chloride injection and 5% glucose injection .METHODS：The appearance of ylate injection in 0.9% sodium chloride injection and 5% glucose injection was observed, with its pH measured and ultraviolet spectra observed.The injection with etamsylate injection in 0.9% sodium the mixture of gatifloxacin for injection with etamsat room temperature, i .e. （20 ±1）℃ within 8 hours contents of gatifloxacin and etamsylate were determined by a dual ultraviolet spectrophotometry.RESULTS： No significant change was noted for the mixture within 8 h in pH and appearance, and the contents of gatifloxacin and etamsylate within 8 h in 0.9% sodium chloride iniection or within 6 h in 5% glucose injection showed no obvious change.CONCLUSION： Gatifloxacin for injection can be mixed with etamsylate injection in 0.9% sodium chloride injection or 5% glucose iniection.