| 食管癌组织中CD15抗原和组织蛋白酶D的表达及其意义 |
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| 引用本文： | 谷化平,尚培中,李志钢,刘绪友.食管癌组织中CD15抗原和组织蛋白酶D的表达及其意义[J].中国微创外科杂志,1999(4). |
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| 作者姓名： | 谷化平 尚培中 李志钢 刘绪友 |
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| 作者单位： | 中国人民解放军第251医院，中国人民解放军第251医院，中国人民解放军第251医院，中国人民解放军第251医院 张家口 075000，张家口 075000，张家口 075000，张家口 075000 |
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| 摘 要： | 目的;探讨CD15抗原和组织蛋白酶D(Cath-D)在食管癌的表达意义及其相互关系。方法:应用微波-LSAB免疫组化法,探讨65例食管癌组织中CD15和Cath-D的表达阳性率及其相互关系。结果:食管癌CD15和Cath-D阳性率分别为58.5％(38/65)和64.6％(42/65)。CD15和Cath-D表达均与肿瘤分级、浸润、淋巴结转移和预后呈显著有关(P均<0.05)。CD15表达与Cath-D表达相关联。结论:食管癌CD15和Cath-D表达对判断其恶性程度、预测其侵袭转移趋势和预后及指导治疗有重要意义。
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| 关 键 词： | 食管肿瘤 鳞状细胞癌 CD15抗原 组织蛋白酶D 免疫组织化学 |
A study on the association of CD15 antigen expression with cathepsin D in esophageal carcinoma |
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| Gu Huaping,Shang Peizhong,Li Zhigang,et al..A study on the association of CD15 antigen expression with cathepsin D in esophageal carcinoma[J].Chinese Journal of Minimally Invasive Surgery,1999(4). |
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| Authors: | Gu Huaping Shang Peizhong Li Zhigang |
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| Affiliation: | Zhangjiakou city 075000 |
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| Abstract: | Objective:To study the association of CD15 antigen expression with cathepsin D (Cath-D) in esophageal carcinoma. Methods : Microwave-LSAB immunohistochemcal method was used to examine the expression of CD15 antigen and Cath-D in 65 specimens of esophageal carcinoma. Results;The positive rates of CD15 antigen and Cath-D were 58. 5% (38/65) and 64. 6%(42/65) respectively. A significant correlation existed between the expression of CD15 antigen or Cath-D and tumor grade infiltration or lymph nodes metastasis or prognosis (P<0. 05,respetively). There was a relationship between the expression of CD15 antigen and the expression of Cath-D. Conclusion :CD15 antigen and Cath-D expression are important to determine the degree of malignancy and prognosis of esophageal carcinoma. |
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| Keywords: | Esophageal neoplasms Squamous carcinoma CD15 antigen Cathepsin D Immunohistochemistry |
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