肝内胆管结石的肝脏病理观察

目的：探讨肝内胆管结石之肝脏病理变化。方法：对７２例肝内胆管结石的肝叶标本进行病理检查，部分尚行粘液及胶原染色。结果：镜一常见的病变是肝间质炎症、胆管上皮及腺体增生和粘液上皮化生（１００％）肝细胞水肿变性及小叶中央性淤胆。胆蛔症。２例伴肝胆管上皮癌，癌旁胆管上皮及腺体异型增生与癌相移行。３３例见局限于门管区的纤维组织增生。结论：肝内胆管结石与胆道炎症、上皮成分增生及粘液化生相关与胆管上皮癌发生有关

Pathologic observation of 72 cases of hepatolithiasis

Purpose To observe the hepatic pathologic change in cases with hepatolithiasis. Methods Seventy two cases hepatic biopsy samples of hepatolithiasis were studied using HE, complex mucin and collagenous fiber staining. Results The cholangitis, the hyperplasia, mucinous metaplasia of the epithelia and glands in the biliary duct were found. There were frequent cholestasis and hydropic degeneration in the liver cells around the center vena. Nineteen(26 4%) cases were ascariasis. Two(2 8%) cases were cholangicarcinoma, in which the cancer translated to the atypical hyperplasia of the epithilia beside it. Thirty three(45%) cases were fibrous hyperplasia mainly in portal areas. Conclusions Hepatolithtiasis may associate with cholangitis and the mucinous metaplasia of biliary epithilia. Hepatolithiasis may correlate with cholangicarcinoma and it does not result in liver cirrhosis. To cure and prevent the cholangitis and ascariasis thoroughly may be an effective measure to prevent hepatolithiasis.