2型糖尿病老年男性患者骨密度变化研究

目的研究2型糖尿病老年男性患者的骨矿面密度（bone mineral density，BMD）变化，探讨影响其骨密度的可能因素。方法应用双能x线骨密度仪测定60例老年男性2型糖尿病患者的腰椎和股骨颈骨密度，并检测血清和尿液中骨代谢及血糖相关的生化指标，分析影响患者骨密度的可能因素。结果依据患者腰椎或股骨颈的骨密度值，骨质疏松的检出率为20％，骨量减少的检出率为53．3％。相关分析显示，年龄、体重、HbAlc均是与腰椎或股骨的BMD相关的变量，其中体重与腰椎的BMD相关性最高（r=0．254，P〈0．01），HbAlc与股骨的BMD相关性最好（r=-0．224，P〈0．01）。结论老年男性2型糖尿病患者的BMD与年龄、体重、HbAlc相关。

Study on the changes of bone mineral density in elderly man with type-2 diabetes

Objective To explore the possible risk factors that influence bone mineral density （BMD） in the elderly man with type-2 diabetes. Methods Sixty elderly man with type-2 diabetes were subjected to dual-energy X-ray absorptiometry to evaluate the BMD at lumbar spine （LS）, and femoral neck （FN）. Fasting blood and urine samples were taken to check the biochemical levels about bone metablism and blood sugar. The correlations between BMD and other factors were analyzed. Results In this group of patients, the percentage of osteoporosis and osteopenia was 20% and 53.3% in LS or FN site, respectively. Age, Weight, and HbAle were correlated with BMD. Weight of them had the best correlation with BMD at LS （ r = 0. 254, P 〈 0.01 ）, whereas, HbAle had the best correlation with BMD at FN （ r = - 0. 224, P 〈 0. 01 ）. Conclusions Age, Weight, and HbAlc c were correlated with BMD of elderly man with type-2 diabetes.