| 壳聚糖基复合膜的制备及预防术后肌腱粘连功能的研究 |
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| 引用本文： | 刘文,常菁,刘万顺,韩宝芹. 壳聚糖基复合膜的制备及预防术后肌腱粘连功能的研究[J]. 功能材料, 2009, 40(3) |
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| 作者姓名： | 刘文 常菁 刘万顺 韩宝芹 |
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| 作者单位： | 中国海洋大学,生命学院,山东,青岛,266003 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 将改性甲壳素、羧甲基壳聚糖和羟丙基壳聚糖按一定比例共混交联,流延涂布法制备3种多糖共混的壳聚糖基复合膜(CTSb复合膜).以鸡为实验动物模型.切除趾浅屈肌腱,横断趾深屈肌腱,形成趾深屈肌腱断裂动物模型.设置实验组、阳性对照组、阴性对照组和正常对照组,运用粘连等级评分、生物力学测试、组织学检测等方法对复合膜预防肌腱粘连作用进行系统评价.结果表明,CTSb复合膜组肌腱吻合口周围的粘连带、肉芽组织、胶原纤维及成纤维细胞均明显少于阴性对照组,肌腱活动度生物力学测试结果明显优于阴性对照组,说明CTSb复合膜具有良好的预防术后肌腱粘连作用.
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| 关 键 词： | 甲壳素 羧甲基壳聚糖 羟丙基壳聚糖 肌腱 预防粘连 |
Study on preparation of Absorbable chitosan compound membrane and its effect on preventing tendon adhesion |
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| LIU Wen,CHANG Jing,LIU Wan-shun,HAN Bao-qin. Study on preparation of Absorbable chitosan compound membrane and its effect on preventing tendon adhesion[J]. Journal of Functional Materials, 2009, 40(3) |
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| Authors: | LIU Wen CHANG Jing LIU Wan-shun HAN Bao-qin |
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| Affiliation: | College of Marine Life Science;Ocean University of China;Qingdao 266003;China |
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| Abstract: | CTSb compound membrane is prepared according to determined proportion of chitin,CM-chitosan and HP-chitosan.The compound film is prepared by solution casting method with double dehydrated glycerylether linked.Models of repaired flexor tendon of chickens are used to investigate the effect of CTSb membrane on preventing tendon adhesion after operation.All chickens are randomly divided into 4 groups: experimental group,positive control group,negtive control group and normal control group.The adhesion score tes... |
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| Keywords: | chitin carboxymethyl chitosan hydroxypropylated chitosan tendon preventing adhesion |
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