低密度脂蛋白胆固醇水平与冠状动脉病变的关系

目的探讨血清低密度脂蛋白胆固醇（low density lipoprotein cholesterol，LDL—C）水平与冠心病患者冠状动脉病变的关系。方法经选择性冠状动脉造影328例，根据冠状动脉造影结果分为冠心病组和对照组；冠心病组根据病变范围分为单支病变、双支病变、多支病变：根据病变狭窄程度分为轻度、中度、重度狭窄组。分别测定其血脂水平。结果冠心病组甘油三酯、LDL-C和总胆固醇水平明显高于对照组。总胆固醇和LDL—C水平与冠状动脉病变呈正相关；双支病变组与三支病变组明显高于对照组及单支病变组（P〈0．01），中度狭窄组和重度狭窄组明显高于对照组及轻度狭窄组（P〈0．01）。结论总胆固醇与LDL-C能够反映冠心病患者冠状动脉的病变情况，其水平随冠状动脉病变范围及病变程度的加重而升高，可作为预测冠状动脉病变的一个因素。

Association between serum LDL-C levels and coronary artery changes in patients with coronary heart disease

Objectives To investigate the possible relation between the serum low density lipoprotein cholesterol （LDL-C） and coronary artery changes in patients with coronary heart disease （CHD）. Methods Coronary angiography （CAG） was performed in 328 patients. The patients were divided into CHD group and control group. The serum levels of lipids were measured. According to the coronary number of stenosis, CHD group was further divided into 1-vessel group, 2-vessel group and 3-vessel group according to the degree of coronary lesion, CHD group was further divided into light stenosis group, moderate stenosis group and severe stenosis group. Results The levels of total cholesterol （TC）, LDL-C and triglyceride （TG） in CHD patients were significant higher than those in control subjects. The serum levels of TC and LDL-C were significantly related to CHD （P 〈 0.01）. The serum levels of TC and LDL-C were higher in the 2-vessel group and 3- vessel group than in the control group and 1-vessel group （P 〈 0.01）. The serum levels of TC and LDL-C were higher in the moderate stenosis group, severe stenosis group than in the control group and light stenosis group （P〈 0.01）. Conclusions The increasing of TC and LDL-C is an associated with the stenosis degrees and lesion degrees of coronary artery in patients witth CHD which indicated that TC and LDL-C had clinical significance for evaluating the change of degree of coronary artery, lesion. The levels of serum TG in patients with CHD is closely related with risk factors in CHD.