| 肿瘤标志物联合检测对消化系统肿瘤的诊断价值 |
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| 引用本文： | 王秀芹,马宏星,严惟力. 肿瘤标志物联合检测对消化系统肿瘤的诊断价值[J]. 标记免疫分析与临床, 2010, 17(2): 83-86. DOI: 10.3969/j.issn.1006-1703.2010.02.008 |
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| 作者姓名： | 王秀芹 马宏星 严惟力 |
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| 作者单位： | 同济大学附属同济医院输血科,上海,200065;同济大学附属同济医院核医学科,上海,200065;交通大学附属仁济医院核医学科,上海,200001 |
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| 摘 要： | 探讨甲胎蛋白（AFP）、癌胚抗原（CEA）、糖类抗原19-9（CA19-9）、糖类抗原125（CA-125）联合检测对消化系统恶性肿瘤的筛查作用及其适用人群。比较我院行AFP、CEA、CA19-9、CA-125榭则的恶性肿瘤患者和良性消化系疾病患者的四项肿瘤标志物的含量，计算并比较其灵敏度、特异性、准确性、阳性预测值及阴性预测值。结果发现，联合检测CA-125＋CA19-9能明显提高消化道空腔器官的恶性肿瘤诊断的灵敏度，但特异性及阳性预测值下降。联合检测更多的肿瘤标志物并不能使诊断准确性提高。对于消化系统实质器官的恶性肿瘤来说，联合检测肿瘤标志物无实际应用价值。去除肝硬化患者、良性胆道疾病及病毒性肝炎患者可明显提高特异性及灵敏度，联合检测CA-125＋CA19—9对于合适的患者有助于提高消化系统空腔器官恶性肿瘤的早期检出率。
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| 关 键 词： | 肿瘤标志物 甲胎蛋白 癌胚抗原 糖类抗原19-9 糖类抗原125 |
Clinical Value of Combined Detection of Tumor Markers in Diagnosis of Digestive System Neoplasm |
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| WANG Xiu-qin,MA Hong-xing,YAN Wei-li. Clinical Value of Combined Detection of Tumor Markers in Diagnosis of Digestive System Neoplasm[J]. Labeled Immunoassays and Clinical Medicine, 2010, 17(2): 83-86. DOI: 10.3969/j.issn.1006-1703.2010.02.008 |
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| Authors: | WANG Xiu-qin MA Hong-xing YAN Wei-li |
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| Affiliation: | WANG Xiu-qin,MA Hong-xing,YAN Wei-li(Department of Blood Transfusion,Tongji Hospital of Tongji University,Shanghai 200065,China) |
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| Abstract: | To explore the sensitivity and specificity of combined detection of serum AFP,CEA,CA19-9 and CA-125 in malignant tumors of the digestive system,and to explore appropriate population for combined detection of the four tumor markers.Patients suspected of suffering from malignant tumors of the digestive system and had their blood tested for the four tumor markers were included in this study.The sensitivity,specificity,accuracy,positive predictive values and negative predictive values were compared for testing ... |
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| Keywords: | Tumor markers Alpha-fetoprotein Carcinoembryonic antigen Carbohydrate antigen 19-9 Carbohydrate antigen 125 |
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