125I粒子治疗中晚期肺癌的临床特征及疗效观察

目的 观察分析使用放射性125I粒子植入的方法治疗中晚期肺癌的临床疗效.方法 选取我院2014年1 1月至2015年11月无手术指征的30例中晚期肺癌患者作为研究对象.行CT引导下125I粒子植入治疗.术后3个月、6个月、12个月进行随访并复查CT,观察患者的临床疗效.结果 30例肺癌患者中术后3个月临床总有效率为93.3％,6个月后为80％,12个月后为63.3％,近期不良反应出现穿刺点出血11例,少量气胸4例,中量气胸1例,咳血5例,未出现肺部感染、大量胸腔积液等严重并发症,无粒子移位.结论 CT引导下经皮穿刺125I粒子植入治疗非小细胞肺癌临床疗效显著,且创伤小,术后不良反应的发生率低,因而可提高患者的生活质量.

Clinical Characteristics and Therapeutic Effect of 125I Particles in the Treatment of Advanced Lung Cancer

Objective To investigate the clinical characteristics and therapeutic effect of iodine 125 seeds implantation in the treatment of advanced non-small cell lung cancer.Methods 30 patients with advanced nonsmall cell lung cancer in our hospital from November 2014 to November 2015 were selected as the subjects.CT guided radioactive iodine 125 particle therapy were applied on these patients.All patients were followed up for 3 months,6 months and 12 months after the operation.The clinical efficacy of CT was then observed.Results Among 30 cases of patients with lung cancer,at 3 months after surgery,the clinical total effective rate was 93.3％,while after 6 months of 80％,after 12 months of 63.3％.Also,the recent occurrence of adverse reactions were found in 11 cases puncture point bleeding,4 cases of pneumothorax,1 cases of pneumothorax,hemoptysis in 5 cases.There were no pulmonary infection,pleural effusion and other serious complications,also no particle displacement.Conclusion CT guided percutaneous radioactive iodine 125 particles can be used in the treatment of non-small cell lung cancer,its clinical curative effect is remarkable,and causing small trauma,reducing the incidence of adverse reactions,and improving patients' quality of life.