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| 河南食管癌高发区人群食管癌和癌旁组织磷酸化酪氨酸蛋白的变化 | |
| 引用本文： | 冯常炜,齐义军,郭瑞锋,焦新英,李吉林,王立东. 河南食管癌高发区人群食管癌和癌旁组织磷酸化酪氨酸蛋白的变化[J]. 郑州大学学报(医学版), 2002, 37(6): 769-771 |
| 作者姓名： | 冯常炜 齐义军 郭瑞锋 焦新英 李吉林 王立东 |
| 作者单位： | 1. 郑州大学医学院癌症研究室,郑州,450052;郑州大学第二附属医院消化内科,郑州,450003 2. 郑州大学医学院癌症研究室,郑州,450052 3. 林州市姚村食管癌医院病理科,林州,456592 |
| 基金项目： | 国家杰出青年科学基金 3 0 0 2 5 0 16，河南省高校创新人才工程基金，河南省医药卫生创新人才工程基金资助项目 |
| 摘 要： | 目的：探讨食管癌和癌旁组织磷酸化酪氨酸蛋白的变化。方法：17例食管癌切除标本，采用组织病理学和Western印迹技术研究食管癌和癌旁正常组织及各级病变组织中磷酸化酪氨酸蛋白的变化。结果：癌旁正常上皮、基底细胞过度增生、不典型性增生和鳞癌中存在75000，60000和55000 3条区域蛋白，75000最明显。75000区域蛋白半定量结果表明癌与癌旁组织间差异无统计学意义。结论：磷酸化酪氨酸蛋白是食管癌变多阶段演进过程中常见的蛋白类型，意义当需更多的研究证实。 |
| 关 键 词： | 河南 食管癌 高发区 人群 癌旁组织 磷酸化酪氨酸蛋白 |
| 修稿时间： | 2002-06-10 |
Preliminary analysis on phosphotyrosine protein in esophageal cancer and adjacent non-cancer tissues from the patients at high-incidence area for esophageal cancer in Henan |
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| FENG Changwei ,),QI Yijun ),GUO Ruifeng ),JIAO Xinying ),LI Jilin ),WANG Lidong ) )Laboratory for Cancer Research,College of Medicine,Zhengzhou University,Zhengzhou ). Preliminary analysis on phosphotyrosine protein in esophageal cancer and adjacent non-cancer tissues from the patients at high-incidence area for esophageal cancer in Henan[J]. Journal of Zhengzhou University: Med Sci, 2002, 37(6): 769-771 | |
| Authors: | FENG Changwei ) QI Yijun ) GUO Ruifeng ) JIAO Xinying ) LI Jilin ) WANG Lidong ) )Laboratory for Cancer Research College of Medicine Zhengzhou University Zhengzhou ) |
| Affiliation: | FENG Changwei 1,2),QI Yijun 1),GUO Ruifeng 1),JIAO Xinying 3),LI Jilin 3),WANG Lidong 1) 1)Laboratory for Cancer Research,College of Medicine,Zhengzhou University,Zhengzhou 450052 2)Department of Gastroenterology,the Second Affiliated Hospital,Zhengzhou University,Zhengzhou 450003 3)Depatment of Pathology,Yaocun Esophageal Cancer Hospital,Linzhou 456592 |
| Abstract: | Aim: To characterize the change of phosphotyrosine protein in esophageal cancer (EC) and adjacent tissues, and to increase the understanding of esophageal multistage carcinogenesis. Methods: The phosphotyrosine protein was determined by histopathological and Western Blot techniques. Results: p Tyr Western Blot analysis showed that there were three clear protein bands located at the site of 75, 60 and 55 kDa in the EC and adjacent tissues, of which the protein band at 75 kDa was more dramatic in protein expression. Quantitative analysis of the 75 kDa protein showed no significant difference between cancer and adjacent tissues. Conclusion: These results suggest that phosphorylation of tyrosine protein is a common protein type in esophageal multistage carcinogenesis and fruther studies will be needed to explain its significance. |
| Keywords: | phosphotyrosine protein esophageal neoplasm adjacent non cancer tissues |
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