几种抗氧化剂抗再灌注心律失常的作用

１００只麻醉开胸ＳＤ大鼠，结扎左冠状动脉主支５ｍｉｎ后，解除结扎，再灌注６０ｍｉｎ引发心律失常（ＲＡ）。动物分为维生素Ｅ（ＶＥ，５００ｍｇ／ｋｇｉｇ）；维生素Ｃ（ＶＣ，１ｇ／ｋｇｉｍ）；辅酶Ｑ１０（ＣｏＱ１０，２５ｍｇ／ｋｇｉｍ）；超氧化物歧化酶（ＳＯＤ，５０００Ｕ／ｋｇｉｖ）及生理盐水（ＮＳ，１０ｍｌ／ｋｇｉｍ）５组。结果如下：ＮＳ与ＳＯＤ组ＲＡ发生率均为９５％，而ＶＥ、ＶＣ、ＣｏＱ１０分别为３５％、５０％和５５％。ＶＥ及ＶＣ组ＶＦ发生率为１５％，无一例死亡；ＣｏＱ１０、ＳＯＤ、ＮＳｆＲＶＦ发生率分别为２０％、５０％和４５％，死亡数分别占５％、２５％和４０％。此外，再灌注期３种抗氧化剂组与ＳＯＤ组左室功能改善明显。

EFFECTS OF SOME ANTIOXIDANTS ON REPERFUSION-INDUCED ARRHYTHMIAS

eperfusion arrhythmias(RA)were induced by temporary ligation of the left coronary arteryfor 5 min and the released for 60 min in 100 anaesthetized Spraque-Dawley rats Lindergoing openchest.Animals were divided into 5 groups: vitamin E(VE,500 mg/kg ig),vitamin C(VC,1g/kgim),CoQ10(25 mg/kg im),superoxide dismutase (SOD,5 000 U/kg iv)and normal saline(NS,10ml/kg im)groups.The results were as follows:The total incidence of RA was 95%both in NSand SOD groups,while 35%, 50%and 55%in VE,VC and CoQ10 groups,respectively. The inci-dence of ventricular fibrillation(VF)was 1 5%both in VC and VE groups and no death wasfound;20%, 50%and 45%of VF were found in CoQ10,SOD and NS group;the deaths due to VFconstited 5%,25%and 40%in the group of CoQ10,SOD and NS,respectively. The left ventricu-lar function was markedly improved in all the grotips but NS.