| 东莨菪碱对兔主动脉条收缩反应的影响 |
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| 引用本文： | 赵瑞莲,陈锦明.东莨菪碱对兔主动脉条收缩反应的影响[J].徐州医学院学报,1994,14(2):117-119. |
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| 作者姓名： | 赵瑞莲 陈锦明 |
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| 作者单位： | Department of Pharmacology，Second Affiliated Hospital of XuzhouMedical College，Xuzhou，Jiangsu 221002，China |
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| 摘 要： | 用离体兔胸主动脉条研究东莨菪碱（ｓｃｏｐｏｌａｍｉｎｅ，Ｓｃｏｐ）扩张血管作用的可能机理。Ｓｃｏｐ与维拉帕米对ＣａＣｌ２和Ｓｃｏｐ对ＫＣＩ所致兔胸主动脉条收缩的量－效曲线右移，最大反应降低，呈现非竞争性拮抗，其ｐＤ＇２分别为３．４，５．８和３．４。两药能明显抑制ＮＥ的依赖内Ｃａ（２＋）性收缩，Ｓｃｏｐ对ＮＥ的依赖外Ｃａ（２＋）性收缩几无影响，表明Ｓｃｏｐ可能主要作用于电压依赖性的钙通道，阻断Ｃａ（２＋）内流。
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| 关 键 词： | 东莨菪碱 主动脉 血管平滑肌 钙 |
EFFECTS OF SCOPOLAMINE ON CONTRACTION OF RABBIT AORTIC STRPS |
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| Zhao Ruilian,Chen Jinming.EFFECTS OF SCOPOLAMINE ON CONTRACTION OF RABBIT AORTIC STRPS[J].Acta Academiae Medicinae Xuzhou,1994,14(2):117-119. |
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| Authors: | Zhao Ruilian Chen Jinming |
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| Abstract: | Scopolamine(Scop)or verapamil(Ver)inhibited the contraction of isolated rabbit thoracic aortia(TA) induced by CaCl2 and KCl.Scop,like Ver,shifted the dose-response curves of CaCl2 and KCl to the right, and depressed their maximal responses, with the pD'2 values being 3.4 in both eases Scop, like Ver, inhibited the intracellular Ca(2 )-dependent component of NE-induced contraction of aorta, but did not decrease the extracellular Ca(2 )-dependent component. These results suggest that Scop,similar to Ver,mainly acts on the potential-operated calcium channel and blocks the influx of Ca(2 ). |
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| Keywords: | scopolamine verapamil thoracic aorta doseresponse relationship vascular smooth muscle |
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