酒石酸长春瑞滨热敏脂质体血管刺激性和急性毒性初步研究

目的以酒石酸长春瑞滨注射液（VRB—I）为对照制剂，研究酒石酸长春瑞滨热敏脂质体（VRB—TL）的血管刺激性和急性毒性。方法家兔耳缘静脉输注VRB—I和VRB—TL进行血管刺激性考察；小鼠尾静脉输注VRB—I和VRB—TL观察其毒性反应和死亡情况。结果VRB—I具有明显的血管刺激性，VRB—TL对血管没有明显的刺激作用。VRB—TL和VRB—I的小鼠半数致死剂量（LD50）相同，均为36mg·kg^-1。但VRB-TL的最大耐受剂量为23．04mg·kg^-1，高于VRB—I。结论VRB—TL安全性优于VRB—I。

Study on Vascular Stimulation and Acute Toxicity of Vinorelbine Tartrate Thermosensitive Liposomes

Objective To study the vascular stimulation and acute toxicity of vinorelbine tartrate thermosen-sitive liposomes （VRB-TL） compared with vinorelbine tartrate injection （VRB-I）. Methods Rabbits and Kunming mice were intravenously infused VRB-TL and VRB-I to investigate vascular stimulation and acute toxicity, respec- tively. Results Vascular stimulation in rabbits was not observed after intravenous infusion of VRB-TL or sodium chloride injection, but was observed after intravenous infusion of VRB-I. The LD50 of VRB-TL and VRB-I for mice was identical （36 mg·kg^-1 ） , but the maximum tolerated dosage of VRB-TL was 23.04 mg·kg^-1, which was higher than that of VRB-I. Conclusion The toxic and side effect of VRB-TL is lower than that of VRB-I.