| CD44s及CD44v 6在喉鳞癌组织中的表达 |
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| 引用本文： | 王双乐,杨强,肖伯奎,江远仕,陈恩河.CD44s及CD44v 6在喉鳞癌组织中的表达[J].临床耳鼻咽喉头颈外科杂志,2000,10(10):446-448,I010. |
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| 作者姓名： | 王双乐 杨强 肖伯奎 江远仕 陈恩河 |
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| 作者单位： | 1. 湖北医科大学附属第一医院耳鼻咽喉-头颈外科武汉，430060
2. 广东省汕头市中心医院耳鼻咽喉科 |
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| 摘 要： | 目的：探讨标准型ＣＤ４４（ＣＤ４４ｓ）及变异型ＣＤ４４（ＣＤ４４ｖ６）在喉鳞癌的表达与临床病理特征的关系，及其在喉鳞癌发生发展中的作用。方法：应用免疫组化ＳＰ法检测４６例喉鳞癌及２０例癌旁正常组织中ＣＤ４４ｓ和ＣＤ４４ｖ６的表达情况。结果：ＣＤ４４ｓ在喉鳞癌淋巴结转移者（９４．４％）及Ｔ３－４者（９６．２％）的表达水平，较无淋巴结转移者（６７．９％）及Ｔ１－２者（５５．０％）高；ＣＤ４４ｖ６在喉鳞
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| 关 键 词： | 喉肿瘤 鳞状细胞癌 淋巴转移 CD44s CD44v6 |
| 修稿时间： | 2000年2月22日 |
Expression of CD44s and CD44v6 in laryngeal squamous cell carcinoma and their significance |
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| WANG Shuang-le,YANG Qiang,XIAO Bai-kui,JIANG Yuan-shi,CHEN En-he.Expression of CD44s and CD44v6 in laryngeal squamous cell carcinoma and their significance[J].Journal of Clinical Otorhinolaryngology,2000,10(10):446-448,I010. |
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| Authors: | WANG Shuang-le YANG Qiang XIAO Bai-kui JIANG Yuan-shi CHEN En-he |
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| Affiliation: | Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Hubei Medical University, Wuhan 430060. |
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| Abstract: | OBJECTIVE: To study the correlation between the expression of CD44s, CD44v6 and the clinicopathological characters of laryngeal squamous cell carcinoma (LSCC) so as to analyze the role of them in occurrence and progression of LSCC. METHOD: Expression of CD44 and CD44v6 in 46 cases of LSCC and 20 cases of adjacent normal tissues was inspected with immunohistochemical SP method. RESULT: The expression of CD44s increased significantly in lymphnode metastasis group (94.4%) and stage III-IV group (96.2%), but decreased in non-lymphnode metastasis group (67.9%) and stage I-II group (55.0%). The expression of CD44v6 was lower (21.7%), which wasn't associated with any clinicopathological characters. CONCLUSION: The role of CD44 and CD44v6 in carcinoma maybe dependent on the species, type of carcinoma, and the expression of CD44s may be a biologic marker to evaluate metastasis of LSCC. |
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| Keywords: | Antigens CD44 Laryngeal neoplasms Squamous cell carcinoma Lymphatic metastasis |
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