不同靶浓度舒芬太尼复合异丙酚对全麻诱导期间血流动力学的影响

目的:比较不同效应室靶控浓度舒芬太尼对丙泊酚全麻患者诱导期间血流动力学的影响.方法:择期全身麻醉患者45例,ASA Ⅰ～Ⅱ级,随机分为Ⅰ-Ⅲ组,分别对应的舒芬太尼效应室靶控浓度为0.4 ng/mL、0.6 ng/mL、0.8 ng/mL.观察3组病例在麻醉诱导前、气管插管前、气管插管后1、3、5分钟收缩压(SBP)、舒张压(DBP)、心率(HR)2,并进行统计学分析.结果:除T1时点外,Ⅰ组和Ⅱ组患者SBP、DBP、HR在其他各个观测时点较基础值T0差异无统计学意义(P>0.05).Ⅲ组患者在T1、T4时点SBP、HR较其他观测时点明显下降(P<0.05).Ⅰ组和Ⅱ组较Ⅲ组SBP、DBP、HR在T4时点差异有统计学意义(P<0.05).结论:效应室靶控浓度为0.4及0.6ng/mL的舒芬太尼复合异丙酚能为全麻患者在诱导期间提供稳定的血流动力学.效应室浓度进一步增加到0.8ng/mL会产生明显的心血管抑制.

Effects of sufentanil on hemodynamic stability during induction of propofol anesthesia

Objective：To observe the effects of sufentanil on hemodyamic stability during the induction of propopfol anesthesia.Methods：Forty-five patients scheduled for elective general anesthesia,aged 18 to 65year,SAⅠ or Ⅱ,were randomly divided into three groups（n=15） according to the sufentanil target effect compartment site concentration（0.4,0.6,0.8 g/mL）.SBP,DBP,HR were recorded before anesthesia（T0）,after the induction before tracheal intubation（T1）,1,3,5 min after tracheal intubation（T2～T4）.Results：There were no significant difference between group I and group Ⅱ（P0.05）.In group Ⅲ,SBP and HR decreased significantly in T1 and T4 compared to group Ⅰ and Ⅱ（P0.05）.Conclusion：The effect site concentration of sufentanil at 0.4 and 0.6 ng/mL is effective for the induction of propofol anesthesia.There is no need for further increase.