| 脂肪族聚氨酯/磷灰石复合材料的原位制备及性能 |
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| 引用本文： | 刘浩怀,张利,左奕,李吉东,邹琴,李玉宝. 脂肪族聚氨酯/磷灰石复合材料的原位制备及性能[J]. 功能材料, 2010, 41(2) |
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| 作者姓名： | 刘浩怀 张利 左奕 李吉东 邹琴 李玉宝 |
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| 作者单位： | 1. 四川大学,纳米生物材料研究中心,分析测试中心,四川,成都,610064;中国测试技术研究院,四川,成都,610021
2. 四川大学,纳米生物材料研究中心,分析测试中心,四川,成都,610064 |
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| 基金项目： | 国家高技术研究发展计划(863计划)重点资助项目(2007AA03Z328766) |
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| 摘 要： | 为避免芳香族聚氨酯在体内降解时产生有毒物质,选用生物相容性良好的脂肪族聚氨酯(PU)与生物活性的羟基磷灰石(HA)为原料,通过原位聚合法制备了脂肪族PU/HA组织工程用多孔支架,并采用SEM、IR和力学试验等方法对多孔支架的形貌和性能进行了表征,进一步研究了发泡剂(水)用量和HA含量对支架泡孔结构和力学强度的影响。结果表明,当发泡剂用量为1%～1.5%(质量分数)时制得的多孔PU/HA复合支架材料孔隙之间相互贯通,孔径范围分布在300～800μm,大孔壁上分布着孔径为50～200μm的小孔,孔隙率达80%以上。随HA含量增加,支架抗压强度和弹性模量显著上升。综合考虑HA的增强效果和组织工程支架的孔隙结构,本体系中HA的最佳添加量为40%(质量分数),发泡剂的最佳用量为1%(质量分数)。
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| 关 键 词： | 脂肪族聚氨酯 磷灰石 复合材料 原位聚合 发泡剂 |
Preparation and properties of aliphatic polyurethane/hydroxyapatite composites by in situ polymerization |
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| LIU Hao-huai,ZHANG Li,ZUO Yi,LI Ji-dong,ZOU Qin,LI Yu-bao. Preparation and properties of aliphatic polyurethane/hydroxyapatite composites by in situ polymerization[J]. Journal of Functional Materials, 2010, 41(2) |
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| Authors: | LIU Hao-huai ZHANG Li ZUO Yi LI Ji-dong ZOU Qin LI Yu-bao |
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| Affiliation: | 1.The Research Center for Nano-Biomaterials;Analytical and Testing Center;Sichuan University;Chengdu 610064;China;2.National Institute of Measurement and Testing Technology;Chengdu 610021;China |
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| Abstract: | In order to avoid toxic degradation products of aromatic polyurethanes in vivo,aliphatic polyurethanes with good biocompatibility and bioactive hydroxyapatite were selected to fabricate porous PU/HA scaffolds for tissue engineering by in situ polymerization.The morphology and properties of the scaffolds were characterized by SEM,IR,and mechanical testing.The effects of the amount of blowing agent(water) and HA content on the pore structure and mechanical strength of scaffolds were investigated.The results i... |
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| Keywords: | aliphatic polyurethane hydroxyapatite composite in situ polymerization blowing agent |
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