Scrub Typhus-Associated Hemophagocytic Syndrome |
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| Authors: | Y-C Chen T-Y Chao J-C Lin |
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| Affiliation: | (1) Div. of Hematology/Oncology, Tri-Service General Hospital, No. 8, Section 3, Ting-Chow Rd., Taipei, Taiwan, Republic of China; Phone: +886-2-23685298, Fax: +886-2-23658544, e-mail: j0607@ms6.hinet.net, TW;(2) Div. of Hematology/Oncology, Dept. of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China, TW;(3) Div. of Infectious Disease, Dept. of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China, TW |
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| Abstract: | Summary
A patient was admitted to our hospital with fever of unknown origin, lymphadenophathy and moderate anemia. The diagnosis of
scrub typhus (tsutsugamushi disease) was established on specific serologic demonstration of antibodies to the cross-reacting
proteins OX-K antigen and reaffirmed by successful treatment with doxycycline. The diagnosis of hemophagocytic syndrome (HPS)
was made on the cytologic findings of many histiocytes containing phagocytosed blood cells in the marrow aspirate. The hemophagocytosis
phenomenon disappeared after the scrub typhus was successfully treated, thus suggesting the relationship between scrub typhus
and hemophagocytosis. In a patient with rickettsial diseases including scrub typhus, associated with HPS, it is important
to understand the relationship between the two disorders since the prognosis for HPS, if untreated, is very poor.
Received: December 8, 1999 · Revision accepted: January 30, 2000 |
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| Keywords: | Hemophagocytic syndrome Scrub typhus |
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