| 口蹄疫病毒样颗粒研究进展 |
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| 引用本文： | 魏婕,魏玉荣,易忠.口蹄疫病毒样颗粒研究进展[J].国外畜牧学(草食家畜),2015(4):6-10. |
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| 作者姓名： | 魏婕 魏玉荣 易忠 |
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| 作者单位： | 新疆畜牧科学院兽医研究所,新疆 乌鲁木齐,830000 |
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| 基金项目： | 新疆维吾尔自治区自然基金青年基金项目 |
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| 摘 要： | 病毒样颗粒(VLP)具有与真实病毒粒子大小相似的结构,能引起免疫应答但不具有感染性。口蹄疫病毒是无囊膜的RNA病毒,其结构蛋白可组装成VLP,且具有良好的免疫原性。本文对口蹄疫病毒VLP的免疫机制、表达系统及应用、口蹄疫病毒VLP作为抗原在诊断和疫苗中的应用进行了综述。
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| 关 键 词： | 蹄疫病毒 病毒样颗粒 疫苗 |
Advance of Virus-like Particles of Foot-and-Mouth Disease |
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| WEI Jie,WEI Yu-rong,YI Zhong.Advance of Virus-like Particles of Foot-and-Mouth Disease[J].Grass-Feeding Livestock,2015(4):6-10. |
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| Authors: | WEI Jie WEI Yu-rong YI Zhong |
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| Abstract: | Virus-like particles (VLPs)share the similar structure and immunogenicitywith natural virus particles except absent of viral genes, but still are able to induce the antigen-antibody response, thus could beuse as a promising platform for vaccines.The foot-and-mouth disease virus (FMDV) belongs to the Picornaviridae family and consists of non-enveloped particles that contain a positive-sense, single-stranded RNA of approximate 8.5 kb. The P1-2A precursor is processed by viral protease 3C to produce the structural proteins VP0, VP1 and VP3. These proteins could self-assemble to formempty capsid-like particles. This review will focus on the immunologic mechanism,expression system and application of FMDV VLPs as antigen in vaccine and diagnosis. |
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| Keywords: | FMDV VLPs vaccine |
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