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N-hexane Alters the Maturation of Oocytes and Induces Apoptosis in Mice |
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| Authors: | LIU Jin HUANG Lei SUN Yan LI Yu Chen ZHU Jian Lin WANG Wen Xiang ZHANG Wen Chang |
| Affiliation: | LIU Jin (Key Laboratory of Environment and Health of Fujian key universities, Fujian Medical University, Fuzhou 350004, Fujian, China)； HUANG Lei (Key Laboratory of Environment and Health of Fujian key universities, Fujian Medical University, Fuzhou 350004, Fujian, China)； SUN Yan (Fujian Provincial Hospital of Maternal and Child Health Care, Fuzhou 350004, Fujian, China)； LI Yu Chen (Key Laboratory of Environment and Health of Fujian key universities, Fujian Medical University, Fuzhou 350004, Fujian, China)； ZHU Jian Lin (Key Laboratory of Environment and Health of Fujian key universities, Fujian Medical University, Fuzhou 350004, Fujian, China)； WANG Wen Xiang (Department of Food, Health and Nutrition Science, University of Public Health and Key Laboratory of Environment and Health, Fujian Medical University, Fuzhou 350004, Fujian, China)； ZHANG Wen Chang (Key Laboratory of Environment and Health of Fujian key universities, Fujian Medical University, Fuzhou 350004, Fujian, China)； |
| Abstract: | ObjectiveThis study was aimed to determine the effects of n-hexane on the maturation of mouse oocytes.MethodsCell culture was used to observe the maturation of mouse oocytes and CLSM was employed to determine their apoptosis.ResultsGerminal vesicle breakdown (GVBD) and extrusion of the first polar body in mouse oocytes were significantly inhibited by n-hexane. After fertilization, the number of eggs in the mouse was significantly reduced by n-hexane. Mitochondrial membrane potentials (Δψm) were altered in mouse oocytes that were leading to apoptosis of the oocytes.ConclusionN-hexane might have affected the maturation of oocytes, causing alteration of Δψm and leading to apoptosis which maybe one of the most important mechanisms. |
| Keywords: | N-hexane Maturation Fertilization Mitochondrial membrane potential |
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