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Synthesis of mono-substituted derivatives of 6-aminoquinoline |
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| Authors: | Tian Lan Xian Xia Yuan Jiang Hong Yu Chao Jiaa Yu Shi Wanga Hui Juan Zhanga Zi Feng Maa Wei Dong Yec a School of Chemistry Chemical Engineering Shanghai Jiaotong University Shanghai China b School of Pharmacy China c Xinchang Pharmaceutical Factory Zhejiang Pharmaceutics CoLtd Xinchang China |
| Affiliation: | a School of Chemistry and Chemical Engineering, Shanghai Jiaotong University, Shanghai 200240, China;b School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, China;c Xinchang Pharmaceutical Factory, Zhejiang Pharmaceutics Co. Ltd., Xinchang 312500, China |
| Abstract: | Several 6-aminoquinoline derivatives,which could be used in drug design,have been synthesized.The reaction conditions were comparatively studied,and the p-chloroaniline was used as optimum oxidant in Skraup-Doebner-Von Miller reaction.The nitro group was reduced effectively by SnCl_2 with no halo-removed occurred. |
| Keywords: | 6-Aminoquinoline 6-Nitroquinoline Skraup reaction Oxidant |
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