The interaction of an anti-tumour platinum complex with DNA. |
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| Authors: | I A Roos |
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| Affiliation: | Department of Physical and Inorganic Chemistry, University of Adelaide, Adelaide S.A. 5001 Australia |
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| Abstract: | The interaction of the anti-tumour active cis platinum (II) complexes with DNA has been investigated using dichloro(ethylenediamine)platinum(II) and E. coli DNA. Equilibrium dialysis studies indicate that Pt(en)Cl2 binds reversibly to DNA to a saturation value of 0.57 Pt: P, which is consistent with the platinum being bound both monofunctionally and bifunctionally. Pt(en)Cl2 inhibits the intercalation of 9-aminoacridine (9AA) by cross-linking the bases of the double helix, but at no stage does all the bound platinum cross-link. It is suggested that this inhibition of intercalation is due to intrastrand cross-linking. |
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| Keywords: | 9AA 9-aminoacridine |
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