| 组织蛋白酶D在涎腺腺样囊性癌表达的研究 |
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| 引用本文： | 彭歆,俞光岩,高岩,武登诚. 组织蛋白酶D在涎腺腺样囊性癌表达的研究[J]. 中华口腔医学杂志, 2000, 35(3): 206-208 |
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| 作者姓名： | 彭歆 俞光岩 高岩 武登诚 |
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| 作者单位： | 1. 北京医科大学口腔医学院口腔颌面外科,100081
2. 北京医科大学口腔医学院病理科,100081 |
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| 摘 要： | 目的 探讨组织蛋白酶Ｄ（ｃａｔｈｅｐｓｉｎ－Ｄ，Ｃａｔｈ－Ｄ）与涎腺腺样囊性癌（ＳＡＣＣ）预后的关系。方法 采用免疫组织化学链亲和素法分析５２例ＳＡＣＣ的Ｃａｔｈ－Ｄ表达，并统计学分析Ｃａｔｈ－Ｄ与ＳＡＣＣ病理学分型、临床分期、局部复发、远处转移和患者生存率的关系。结果 Ｃａｔｈ－Ｄ表达与ＳＡＣＣ病理学分型、局部复发和患者生存率无明显相关（Ｐ〉０．０５），而与临床分期和远处转移呈正相关关系（Ｐ〈０
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| 关 键 词： | 组织蛋白酶D 免疫组织化学 涎腺腺样囊性癌 |
| 修稿时间： | 1999-03-05 |
The expression of cathepsin-D in salivary adenoid cystic carcinoma |
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| X Peng,G Yu,Y Gao. The expression of cathepsin-D in salivary adenoid cystic carcinoma[J]. Chinese journal of stomatology, 2000, 35(3): 206-208 |
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| Authors: | X Peng G Yu Y Gao |
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| Affiliation: | Department of Oral Maxillofacial Surgery, School of Stomatology, Beijing Medical University, Beijing 100081, China. |
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| Abstract: | Objective To investigate the relationship between Cathepsin D(Cath D) and the prognosis of patients with salivary adenoid cystic carcinoma (SACC) Methods The immunoactivity of Cath D of 52 cases with SACC was determined by immunohistochemistry method (Streptavidin Biotin method) The relationship between Cath D and the histological type, clinical stage, local recurrence, distant metastasis of the tumor and survival rate of the patients with SACC were analysed Results Statistical analysis showed that the expression levels of Cath D were correlated positively with distant metastasis potential and clinical stage ( P <0 05), and had no significant relation with histological type, local recurrence and survival rate ( P >0 05) Conclusions Cath D can facilitate invasiveness and distant metastasis of SACC; evaluation of Cath D can act as a predictor of distant metastasis of SACC and direct the clinical treatment |
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| Keywords: | Salivary gland neoplasms Carcinoma adenoid cystic Cathepsin D Immunohistochemistry |
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