1,2-Propanediol-induced changes in plasma and tissue lipids of rats |
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| Authors: | M K P Amma H M Dani Pushpa Ahluwalia Aruna Dhingra Jaswinder Kaur Charanjit Kaur Sushma Sharma Kamlesh Jain Sarvpreet Singh K Sareen |
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| Affiliation: | (1) Department of Biochemistry, Panjab University, Chandigarh, India |
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| Abstract: | Oral administration of 1,2-propanediol to rats in a daily dose of 1 ml of 28.4% aqueous solution per 100 g body weight for
30 days caused a significant decrease in the total lipids, fatty acids, phospholipids, and triglycerides of plasma, liver,
and heart, The cholesterol content in plasma decreased while that in the tissues increased significantly. The accumulation
of cholesterol in tissues tends to discourage long term use of 1,2-propanediol even by the oral route. |
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