| 聚多巴胺辅助溶胶-凝胶TiO_2薄膜表面固定牛血清白蛋白 |
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| 引用本文： | 孙见敏,;付涛,;吴锋,;刘芸,;张红梅,;孙嘉懋. 聚多巴胺辅助溶胶-凝胶TiO_2薄膜表面固定牛血清白蛋白[J]. 生物医学工程研究, 2014, 0(4): 245-250 |
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| 作者姓名： | 孙见敏, 付涛, 吴锋, 刘芸, 张红梅, 孙嘉懋 |
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| 作者单位： | [1]西安交通大学生命科学与技术学院生物医学信息工程教育部重点实验室,西安710049; [2]西安交通大学医学院,西安710061; [3]西安交通大学理学院化学系,西安710049 |
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| 基金项目： | 国家自然科学基金资助项目（50901058）; 中央高校基本科研业务费专项资金资助项目（xjj2011096） |
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| 摘 要： | 在钛表面涂覆溶胶-凝胶TiO2薄膜,再利用聚多巴胺薄膜结合牛血清白蛋白(BSA)分子,以改善血液相容性。X射线光电子能谱分析表明TiO2薄膜表面形成了聚多巴胺薄膜和BSA分子层。接触角测试结果表明聚多巴胺薄膜和BSA分子层使试样的接触角升高,但表面能和界面张力下降。血液相容性实验表明,与TiO2涂层试样相比,结合BSA分子的试样具有更好的抗凝血性能和抗血小板聚集性能。
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| 关 键 词： | 钛 TiO2 溶胶-凝胶 多巴胺 牛血清白蛋白 血液相容性 |
Polydopamine Assisted Immobilization of Bovine Serum Albumin on Sol-gel TiO_2 Film |
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| Affiliation: | SUN Jianmin,FU Tao,WU Feng,LIU Yun,ZHANG Hongmei,SUN Jiamao (1. Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi＇ an Jiaotong University, Xi＇ an 710049, China; 2. College of Medicine, Xi＇ an Jiaotong University, Xi＇ an 710061 ; 3. Department of Chemistry, School of Science, Xi＇an Jiaotong University, Xi＇an 710049) |
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| Abstract: | Sol-gel TiO2 film was coated on Ti substrate and then polydopamine film was utilized to immobilize bovine serum albumin（ BSA） molecules to improve the hemocompatibility of TiO2 film. The analysis of X-ray photoelectron spectroscopy indicated that polydopamine film and BSA molecule layer were formed at TiO2 film surface. The results of contact angle measurement showed that the polydopamine film and BSA molecule layer increased contact angle,but decreased surface energy and interface tension of the sample.The hemocompatibility tests demonstrat that the sample with BSA molecules layer has better anti-thrombogenic activity and anti-aggregating function compared with the TiO2 coated sample. |
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| Keywords: | Ti TiO2 Sol-gel Dopamine Bovine serum albumin Hemocompatibility |
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