| 参附注射液保护阿霉素心肌毒性机理研究 |
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| 引用本文： | 周乐全,康亚丽,闫福曼,罗荣敬. 参附注射液保护阿霉素心肌毒性机理研究[J]. 辽宁中医药大学学报, 2007, 9(3): 209-211 |
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| 作者姓名： | 周乐全 康亚丽 闫福曼 罗荣敬 |
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| 作者单位： | 广州中医药大学,广东,广州,510405 |
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| 摘 要： | 目的:观察参附注射液保护阿霉素心脏毒性的作用机理.方法:急性分离单个心肌细胞,运用TILLVISION钙离子荧光成像及分析系统,观察不同组间单个心肌细胞内游离钙离子的浓度变化.结果:阿霉素可引起心肌细胞内钙离子水平显著升高(P＜0.01),参附注射液干预可显著降低异常心肌细胞内游离钙离子浓度;同时,参附注射液还可抑制咖啡因诱导的内钙释放.结论:参附注射液对阿霉素心脏毒性的保护作用可能是通过抑制肌浆网的内钙释放,避免心肌细胞内钙超载,从而维持细胞内钙离子水平,达到保护心肌的作用.
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| 关 键 词： | 参附注射液 阿霉素 钙浓度 咖啡因 |
| 文章编号： | 1673-842X（2007）03-0209-03 |
| 修稿时间： | 2006-12-25 |
The Mechanism of Shenfu Injection Protect Myocardial Lesion Caused by Adriamycin |
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| ZHOU Le-quan,KANG Ya-li,YAN Fu-man,LUO Rong-jing. The Mechanism of Shenfu Injection Protect Myocardial Lesion Caused by Adriamycin[J]. Journal of Liaoning University of Traditional Chinese Medicine, 2007, 9(3): 209-211 |
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| Authors: | ZHOU Le-quan KANG Ya-li YAN Fu-man LUO Rong-jing |
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| Affiliation: | Guangzhou University of TCM, Guangzhou 510405, Guangdong, China |
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| Abstract: | Objective:To observe the mechanism of Shenfu(SF) injection protect myocardial lesion caused by adriamycin.Methods:The single myocardial cells were isolated acutely,free [Ca2+]i of single myocardial cells were measured by the Tillvision system,to observe the changes of [Ca2+]i at the different groups.Results[:Ca2+]i of adriamycin myocardial lesions were increased significantly(P<0.01).After using SF,free [Ca2+]i of myocardial cell caused by adriamycin were decreased significantly,furthermore,the endo-myocardial cell calcium releasing of caffeine induced was inhabited by SF injection.Conclusions: The protective effects of SF injection might inhibit endo-myocardial cell calcium releasing of sarcoplasmic reticuiumt,o advoid calcium overload induced by adriamycin,to achive the effect of protection myocard. |
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| Keywords: | Shenfu injection adriamycin [Ca2+]i caffeine |
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