深部真菌感染及耐药性分析

目的:了解某医院真菌感染的现状,并对其耐药性进行分析,为临床合理使用抗真菌药物提供依据。方法:某医院门诊及住院患者的各类真菌培养2137份标本进行药敏试验。结果:共分离出真菌162株,162株病原真菌以内科系统为主共114株占70.37%;检出深部真菌最多的部位是呼吸道,占真菌标本的72.02%;真菌以白色假丝酵母菌、热带假丝酵母菌和克柔假丝酵母菌为主,分别占60.49%、19.13%、13.58%;药敏结果:5-氟胞嘧啶、两性霉素B 94%以上敏感,白色假丝酵母菌对氟康唑的耐药率很高,均在69%以上,5种常见抗真菌药物对其他病原真菌的敏感率均在90%以上。结论:加强临床病原性真菌分离株,对抗真菌药物的耐药性检测,然后根据药敏试验结果科学合理选用抗真菌药物十分重要。

Analysis of deep fungals infection and drug resistance

Objective ： To investigate the tendency ot drug resistance and the characteristic ot deep lungus mtechon and to provide the experiment basis for clinical selecting antifungal agents. Methods ： 162 strains of pathogenic fungals collected from our hospital were used to analyse the results of susceptibility test. Results：The major department of those isolated pathogenic fungis was the internal medicine, 114 strains accounted for（70.372% ）,the major site of those isolated pathogenicity fungi was respiratory tract （72.02%） and the major type was C. albicans （60.49%）, C. tropicalis（ 19.13% ）and C. krusei（ 13.58% ）,Candida is the major pathogen to cause fungal infection in hospital,The resistance rates of the hardly using antifungal drugs with greater poisonous side effect in clinics, such as Am photeri- cin,and Flucytosine,are the lowest,while the rate of the frequently using Fluconazole is the highest. Conclusion：En- hancing the detection of drug resistance of deep fungal is important to select correct antifungal agent.