| 大鼠应激性溃疡与胃泌素、胰高血糖素和生长抑素的相关性研究 |
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| 引用本文： | 梁丕霞 张绍东. 大鼠应激性溃疡与胃泌素、胰高血糖素和生长抑素的相关性研究[J]. 首都医科大学学报, 1995, 16(4): 287-289 |
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| 作者姓名： | 梁丕霞 张绍东 |
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| 作者单位： | 首都医学院附属北京天坛医院内科消化组，北京市神经外科研究所 |
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| 摘 要： | 采用冷束缚法建立大鼠应激性溃疡模型，以探讨胃肠激素与应激性溃疡发病的相关性。实验组置于（４±２）℃环境，３Ｈ，对照组置于（１８±３）℃，３ｈ，分别检测不同时间血清胃泌素、胰高血糖素、生长抑素的水平。结果表明，实验组胃泌素、胰高血糖素水平明显高于对照组，生长抑素水平明显低于对照组。提示胃泌素、胰高血糖素、生长抑素可能从不同的角度参与了应激性溃疡的消长过程。
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| 关 键 词： | 应激性溃疡；胃泌素；胰高血糖素；生长抑素 |
| 收稿时间： | 1994-11-07 |
A Study on Links of Stress Ulcer and the Serum Levels of Gastrin Glucagon and Somatostatin in Rats |
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| Liang Peixia, Yang Zhaoxu. A Study on Links of Stress Ulcer and the Serum Levels of Gastrin Glucagon and Somatostatin in Rats[J]. Journal of Capital Medical University, 1995, 16(4): 287-289 |
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| Authors: | Liang Peixia Yang Zhaoxu |
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| Affiliation: | 1. Department of Gastroenterology, Beijing Tiantan Hospital, Capital Institute of Medicine;2. Beijing Neurosurgical Institute |
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| Abstract: | This article deals with the links between three gastrointestino-hormones and irritable ulcer in“cold-ties”induced ulcer model.Our experiment indicated that: ①The serum gastrin levels of the stress group were significantly higher than that of the control.This might be due o the excitement of vagus nerve under stress.② The serum levels of somatostatin in stress group were lower than that of the control ,this indicated that the inhibihition of somatostatin in gastro-secretin was reduced which in turn caused hyperhydrochloria.③The serumglucagon correlated positively with serum gastrin level and negatively with blood sugar.These peptides might function as gastrointestinal hormones and neurotransmitters in the CNSand peripheral nervous system. |
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| Keywords: | stress ulcer gastrin glucagon somatostatin |
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