Association of miRNA 30c,miRNA 181a and miRNA 570 SNPs with Bladder Cancer Risk in North Indian Population: A Pilot Study |
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| Authors: | Archana Verma Rama Devi Mittal |
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| Affiliation: | 1.Department of Ocular Oncology, L V Prasad Eye Institute, Banjara Hills, Hyderabad, Telangana 500034 India ;2.Professor and Emeritus Medical Scientist (ICMR), Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, Uttar Pradesh 226014 India |
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| Abstract: | miRNA play role in post transcriptional regulation of genes and serves a range of biological functions such as initiation, development, metastasis etc. which are also hallmarks of cancer. Hence, we evaluated miRNA 181a, miRNA 30c and miRNA 570 in bladder cancer risk association among North Indians. miRNA 570 C/G (rs4143815), miRNA 30c A/G (rs928508) and miRNA 181a C/T (rs12537) single nucleotide polymorphisms (SNPs) were genotyped by allelic discrimination TaqMan assay in 100 bladder cancer (BC) patients and 100 healthy controls. No significant difference was found in the genotype frequencies of the candidate SNPs among cases and controls. However, combined effect of miRNA 570-miRNA 30c (CG + AA) p = 0.005, OR = 0.223, 95% CI and miRNA 570-miRNA 181a (CG + CC) p = 0.003, OR = 0.169, 95% CI conferred association with no risk of BC. miRNA 181a C/T (rs12537), miRNA 30c A/G (rs928508) and miRNA 570 C/G (rs4143815) should be further validated in large sample size to be used as a risk predictor for bladder cancer among North Indians. |
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| Keywords: | Bladder cancer miRNAs SNPs Cigarette smoking Association |
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