Amino acid N-carboxyanhydrides: activated peptide monomers behaving as phosphate-activating agents in aqueous solution |
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| Authors: | Biron Jean-Philippe Pascal Robert |
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| Affiliation: | Organisation Moléculaire Evolution et Matériaux Fluorés UMR 5073 - CC 017, Département de Chimie, Université Montpellier 2, Place Eugène Bataillon, F-34095 Montpellier, France. |
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| Abstract: | The hydrolysis of valine N-carboxyanhydride (NCA) in aqueous phosphate buffers was shown to proceed through nucleophilic catalysis via an aminoacyl phosphate intermediate that displays phosphorylating capabilities through a potentially prebiotic process that simulates modern biochemical metabolic pathways. |
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