| 紫外光诱导晶状体上皮细胞凋亡的研究 |
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| 引用本文： | 赵长松,邹尉玉,孙旭芳. 紫外光诱导晶状体上皮细胞凋亡的研究[J]. 中国现代医学杂志, 2001, 11(1): 35-36 |
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| 作者姓名： | 赵长松 邹尉玉 孙旭芳 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院眼科 |
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| 摘 要： | 目的研究紫外光(ultravioletUV)诱导的晶状体上皮细胞(lensepithelialcell LEC)凋亡特征。方法100mw/m
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| 关 键 词： | 凋亡 晶状体上皮细胞 紫外光 白内障 |
| 修稿时间： | 2000-10-28 |
APOPTOSIS OF LENSEPITHELIAL CELL INDUCED BY ULTRAVIOLET |
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| Abstract: | Objective:To investigate the apoptosis of lens epithelial cell induced by ultraviolet.Methods：Vistar rats received 100mw/m2 ultraviolet irradition(UVR)(λ 280nm-315nm) for 15 minutes.At h1,6,24 after irradition the lens capsules were dissected and the percentage of apoptotic cells were evaluted by the TdT-dUTP terminal nick-end labeling(TUNEL) technique.The morphological changes were observed by transmission electron microscope.Results：TUNEL-positive nuclei were found at only 24 hours after UVR exposure and the percentage is 14.3%.Cell chromatin condensation was observed by transmission electron microscope.Conclusions：Our results showed that UVR can induce the rapid apoptotic death of the lens epithelial cells. |
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