| 母亲年龄与先天性甲状腺功能减低症的关联分析 |
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| 引用本文： | 王丽雯,赵德华,张小安,何婧文,罗春伟. 母亲年龄与先天性甲状腺功能减低症的关联分析[J]. 现代预防医学, 2021, 0(2): 373-377 |
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| 作者姓名： | 王丽雯 赵德华 张小安 何婧文 罗春伟 |
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| 作者单位： | 郑州大学第三附属医院 新生儿疾病筛查中心，河南 郑州450052 |
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| 摘 要： | 目的 研究母亲年龄与先天性甲状腺功能减低症(CH)之间的关联.方法 采用病例-对照研究设计,以2016年1月1日-2017年12月31日由河南省新生儿疾病筛查中心确诊的CH患儿作为病例组,按照1:1比例匹配同性别、出生日期不超过30d的健康新生儿作为对照组.采用条件logistic回归及限制性立方样条分析CH的风险因素...
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| 关 键 词： | 先天性甲状腺功能减低症 病例-对照研究 限制性立方样条分析 |
Analysis of association between maternal age and congenital hypothyroidism |
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| WANG Li-wen,ZHAO De-hua,ZHANG Xiao-an,HE Jing-wen,LUO Chun-wei. Analysis of association between maternal age and congenital hypothyroidism[J]. Modern Preventive Medicine, 2021, 0(2): 373-377 |
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| Authors: | WANG Li-wen ZHAO De-hua ZHANG Xiao-an HE Jing-wen LUO Chun-wei |
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| Affiliation: | Neonatal Disease Screening Center, The Third Affiliate Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China |
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| Abstract: | Objective To investigate the association between maternal age and congenital hypothyroidism(CH). Methods A case-control study was conducted. Children diagnosed with CH during January 1 st, 2016 and December 31 st, 2017 at the Newborn Disease Screening Center of Henan Province were assigned as the case group and healthy newborns of the same sex with length of birth less than 30 days as the control group according to 1:1 ratio. Conditional logistic regression and restricted cubic spline analysis were performed to analyze the risk factors of CH. Results A total of 843 pairs of case-control were enrolled in this study. Taking the age group of 21-<26 years as reference, CH risk rose in the advanced delivery age groups of 26-<31 years, 31-<35 years, and ≥35 years(OR |
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| Keywords: | Congenital hypothyroidism Case-control study Restricted cubic spline regression model |
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