p28GANK在胰腺导管癌中表达的临床意义

目的：探讨p28GANK在胰腺导管癌中表达及其临床意义。 方法：用免疫组化法检测p28GANK在48例胰腺导管癌及其癌旁组织中的表达，分析p28GANK胰腺导管癌中表达与患者临床病理因素及术后生存率的关系。 结果：p28GANK在胰腺导管癌组织中阳性表达率明显高于对应的癌旁组织（P<0.01）；p28GANK在胰腺导管癌组织中高表达与高TNM分期、低级别分化程度、转移有关（均P<0.05），而与患者性别及年龄无关（均P>0.05）。p28GNAK阳性患者术后3年生存率明显低于阴性表达者（P=0.01）。 结论：p28GANK在胰腺导管癌中表达上调，其高表达与患者恶性进展程度密切相关。

P28GANK expression in pancreaticductal carcinoma and its clinical significance

Objective: To investigate the p28GANK expression in pancreatic ductal carcinoma and its clinical significance. Methods: The p28GANK expression in pancreatic ductal cancer and matched adjacent non-cancerous tissues from 47 patients were determined by immunohistochemical staining. The relations of p28GANK expression in pancreatic ductal cancer with the clinicopathologic factors and postoperative survival of the patients were analyzed. Results: The p28GANK expression in pancreatic ductal cancer tissues was significantly higher than that in their adjacent non-cancerous tissues (P<0.01). The high p28GANK expression in tumor tissue was significantly associated with advanced TNM stage, low differentiation, and metastases(all P<0.05), but was irrelevant to age and gender of the patients (both P>0.05).The 3-year postoperative survival rate in patients with p28GANK positive expression was significantly lower than that in those with p28GANK negative expression (P=0.01). Conclusion: p28GANK expression is up-regulated in pancreatic ductal carcinoma, and high p28GANK expression is closely related to the progress of malignancy stage.