Clinicopathologic characteristics of laryngeal chondrosarcoma: An analysis of the National Cancer Database |
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| Authors: | Janet O. Adeola Jimmy S. Patel Roman Povolotskiy Gregory L. Barinsky Jordon G. Grube Wayne D. Hsueh Soly Baredes Jean Anderson Eloy |
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| Affiliation: | 1. Department of Otolaryngology – Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ, United States;2. Division of Otolaryngology/Head and Neck Surgery, Department of Surgery, Albany Medical Center, Albany, NY, United States;3. Center for Skull Base and Pituitary Surgery, Neurological Institute of New Jersey, Rutgers New Jersey Medical School, Newark, NJ, United States;4. Department of Neurological Surgery, Rutgers New Jersey Medical School, Newark, NJ, United States;5. Department of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, NJ, United States;6. Department of Otolaryngology and Facial Plastic Surgery, Saint Barnabas Medical Center - RWJBarnabas Health, Livingston, NJ, United States;1. Department of Surgery–Otorhinolaryngology Head and Neck Surgery, the Queen Elizabeth Hospital, and the University of Adelaide, Adelaide, SA 5061, Australia;2. Department of Otolaryngology-Head and Neck Surgery, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, Hokkaido 060-8638, Japan;1. Department of Otorhinolaryngology, Head & Neck Surgery, School of Medicine, Kyung Hee University, Seoul, Republic of Korea;2. Department of Plastic and Reconstructive Surgery, School of Medicine, Kyung Hee University, Seoul, Republic of Korea;3. Department of Otorhinolaryngology, Head and Neck Surgery, Kangdong Sacred Heart Hospital, Seoul, Republic of Korea;1. Department of Otolaryngology–Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;2. Department of Ophthalmology, Show Chwan Memorial Hospital, Changhua, Taiwan;3. Graduate Institute of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan;1. Fudan University, Shanghai, China;2. Department of Otology and Skull Base Surgery, Eye Ear Nose & Throat Hospital, Fudan University, Shanghai 200031, China;3. Shanghai Auditory Medical Center, Shanghai, China;4. Key laboratory of Hearing Science, Ministry of Health, Shanghai, China;5. Department of Economics, London School of Economics and Political Science, London, United Kingdom;6. Department of Power Mechanical Engineering, National Formosa University, Yunlin, Taiwan;7. Numerical and Scientific Computing Laboratory, National Formosa University, Yunlin, Taiwan |
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| Abstract: | ObjectivesLaryngeal Chondrosarcoma (LC) is a rare malignancy with limited studies documenting its clinicopathologic characteristics and treatment options. This study reports demographic and clinical determinants of outcomes for this rare tumor.MethodsThe National Cancer Database (NCDB) was queried for cases of LC reported from 2004–2016. 274 cases that met inclusion criteria were analyzed for demographic and clinicopathologic characteristics. Kaplan-Meier (KM) and Cox proportional hazard analyses were conducted to identify variables that impacted the overall survival of these patients.ResultsLC was found to be more common in males (74.8%). The mean age of patients was 61.8 years and 92.3% of the patients were white. 91.3% of patients were treated with only surgical resection, most commonly: partial laryngectomy (31.6%), total laryngectomy (25.7%), and local resection (22.4%). 98.8% of patients had no evidence of nodal disease and 99.6% of patients did not have distant metastasis at presentation. KM analysis revealed a 5-year overall survival (5YOS) of 89.0%. Age, insurance status, facility type, and surgery type were significant predictors of 5YOS (p<0.05). On Cox Proportional Hazard analysis, private insurance significantly improved survival (HR 0.21; p = 0.048) while increasing age was a poor prognostic indicator (HR 1.10; p = 0.004).ConclusionThe majority of LC patients present with no nodal involvement or distant metastasis at diagnosis, and overall this tumor has a favorable prognosis. Increasing age was found to be a poor prognostic factor while private insurance status was associated with improved survival. |
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