不同类型的急性脑梗死患者辅助性T细胞及甲基CpG结合蛋白2表达水平变化及其临床意义

目的 探讨不同类型的急性脑梗死患者辅助性T细胞(CD4+T cells,CD4+T细胞)及甲基CpG结合蛋白2(Methyl-CpG-binding protein 2,MECP2)表达水平变化及其临床意义.方法 选取本院2017年2月-2019年2月收治的急性脑梗死患者156例作为病例组,按照请奥加兰(Orgaran...

The levels of regulatory T cells and MeCP2 protein in patients with different types of acute stroke

ObjectiveTo explore the levels of regulatory T cells and methyl-CpG-binding protein 2(MeCP2)in patients with different types of acute stroke.Methods 156 patients with acute cerebral infarction between February 2017 to February 2019 were enrolled in this study. The patients were classified based on the TOAST(Trial of ORG 10172 in Acute Stroke Treatment)classification. Group A(n=82, large artery atherosclerosis), group B(n=33, cardiogenic embolism)and group C(n=41, small artery occlusion). 155 healthy subjects were enrolled as the control group. The number of CD4⁺ T cells and the expression levels MeCP2 in the peripheral blood were analyzed.Results The number CD4⁺ T cells in group A were significantly lower than those in group B, group C, and the control group(P<0.05); The number of CD4⁺ T cells in group B were significantly higher than those in group C and control group(P<0.05). The MeCP2 expression levels in stroke patients were significantly higher than the control subjects(P<0.05); the MeCP2 levels of group A were significantly higher than that of group B, group C, and the control group(P<0.05).Conclusion The number of CD4⁺ T cells and the levels of MeCP2 varies in different acute stroke subtypes. They may facilitate the classification of acute cerebral infarction.