动态对比增强磁共振成像在局部晚期宫颈癌同步放化疗效果评估中的价值

目的探讨动态对比增强磁共振成像（DCE-MRI）在局部晚期宫颈癌同步放化疗效果评估中的价值。方法选取2019年1月~2020年1月在我院治疗的局部晚期宫颈癌患者200例，所有患者均给予同步放化疗疗效，观察治疗前后DCE-MRI参数变化情况，同时分析治疗有效和无效患者DCE-MRI参数差异。结果200例患者经同步放化疗后，达到完全缓解患者21例，部分缓解患者67例，疾病稳定患者72例，疾病进展患者40例，治疗有效率为44.00%；治疗无效患者FIGO分期ⅣA期比例、卡氏评分高于治疗有效患者（P < 0.05）；治疗后病灶表观扩散系数（ADC）值、容量转移常数（Ktrans）、血管外细胞外间隙容积（Ve）较治疗前升高（P < 0.05）；治疗有效患者病灶ADC变化值、Ktrans变化值、Ve变化值高于治疗无效患者（P < 0.05）；ADC变化值、Ktrans变化值、Ve变化值预测治疗有效的ROC曲线下面积分别为0.675、0.770和0.905（P < 0.05），截断值分别为0.35×10-3 mm2/s、0.54 min-1和0.22，灵敏性分别为66.60%、78.80%和85.50%，特异性分别为62.00%、75.50%和82.00%。结论DCE-MRI在局部晚期宫颈癌同步放化疗效果评估中有一定应用价值，值得临床使用。 

Value of DCE-MRI in evaluation of concurrent chemoradiotherapy for locally advanced cervical cancer

ObjectiveTo investigate the value of dynamic contrast- enhanced magnetic resonance imaging (DCE-MRI) in the evaluation of concurrent chemoradiotherapy for locally advanced cervical cancer.MethodsA total of 200 patients with locally advanced cervical cancer treated in our hospital from January 2019 to January 2020 were selected. All patients were treated with concurrent chemoradiotherapy, the changes of DCE-MRI parameters before and after treatment were observed, and the differences of DCE-MRI parameters between effective and ineffective patients were analyzed.ResultsAll patients received concurrent chemoradiotherapy. There were 21 patients with complete remission, 67 patients with partial remission, 72 patients with stable disease and 40 patients with disease progression, the effective rate was 44.00%. The proportion of FIGO stage ⅣA and Karnofsky score of patients with ineffective treatment were significantly higher than those of patients with effective treatment (P < 0.05). The apparent diffusion coefficient (ADC), volume metastasis constant (Ktrans) and volume of extracellular space (Ve) were significantly higher than those before treatment (P < 0.05). The change values of ADC, Ktrans and Ve in the effective patients were significantly higher than those in the ineffective patients (P < 0.05). The area under the ROC curve of ADC change, Ktrans change and Ve change to predict the treatment effectiveness were 0.675, 0.770 and 0.905 (P < 0.05), and the cutoff values were 0.35×10-3 mm2/s, 0.54 min-1 and 0.22, the sensitivity were 66.60%, 78.80% and 85.50%, and the specificity were 62.00%, 75.50% and 82.00%, respectively.ConclusionDCE-MRI has certain application value in evaluating the effect of concurrent chemoradiotherapy for local advanced cervical cancer and is worthy of clinical use.