热疗辅助放化疗在晚期大肠癌的临床治疗中的应用研究

目的 探讨热疗辅助放化疗对晚期大肠癌疗效的影响.方法 选取106例晚期大肠癌患者为研究对象,分成2组.对照组53例行放化疗,观察组53例在放化疗基础上加用热疗.观察治疗前后2组相关指标的变化情况.结果 对照组有效率为52.83％,观察组有效率为69.81％,观察组显著优于对照组(P＜0.05).2组治疗后NK、CD8+、CD4+较治疗前均显著提高,治疗前后比较差异有统计学意义(P＜0.05);观察组治疗后NK、CD8+、CD4+较对照组治疗后提高更加显著,2组治疗后比较差异有统计学意义(P＜0.05).2组治疗后CEA、CA199、CA242较治疗前均显著下降,治疗前后比较差异有统计学意义(P＜0.05);观察组治疗后CEA、CA199、CA242较对照组治疗后下降更加显著,2组治疗后比较差异有统计学意义(P＜0.05).对照组治疗后躯体、社会、认知、情绪功能较治疗前无明显改善(P＞0.05),观察组治疗后躯体、社会、认知、情绪功能较对照组治疗后提高显著(P＜0.05),2组治疗后躯体、社会、认知、情绪功能等差异有统计学意义(P＜0.05).结论 热疗辅助放化疗在治疗晚期大肠癌中的疗效满意.

Hyperthermia Chemoradiotherapy in the Clinical Treatment of Advanced Colorectal Cancer

Objective To investigate the efficacy of hyperthermia adjuvant chemoradiation for advanced colorectal cancer.Methods 106 cases of advanced colorectal cancer were divided into 2 groups,each with 53 cases.The control group received radiotherapy and chemotherapy,the observation group received hyperthermia therapy on the basis of the control group.Treatmentrelated indicators changes before and after treatment was observed.Results In the control group,the total efficiency was 52.83％,in the observation group,the total efficiency was 69.81％,the observation group was significantly better than the control group (P ＜ 0.05);after treatment,NK,CD8 +,CD4 + significantly improved,there had significant difference (P ＜ 0.05),compared with the control group,NK,CD8 +,CD4 + improved more significantly in the observation group after treatment,there had significant difference (P ＜ 0.05);after treatment,CEA,CA199,CA242 before treatment significantly decreased after treatment,there had significant difference (P ＜ 0.05),CEA,CA199,CA242 in the observation group after treatment decreased more significandy compared with the control group,the difference was significant (P ＜ 0.05);physical,social,cognitive,and emotional function of the control group after treatment had no significant improvement (P ＞0.05),the observation group after treatment physical,social,cognitive,and emotional function of the observation group after treatment compared with the control group had a significant increase (P ＜ 0.05),after treatment,physical,social,cognitive,and emotional function of the 2 groups were significantly different (P ＜ 0.05).Conclusion Hyperthermia chemoradiotherapy for advanced colorectal cancer is satisfactory.