儿童过敏性结膜炎与变应性疾病的相关性

目的评价儿童过敏性结膜炎与变应性鼻炎、哮喘及湿疹的相关性。方法对2005年9月～2006年9月在本院就诊的407例儿童过敏性结膜炎进行回顾性分析。对其鼻炎、哮喘、湿疹以及父母的过敏性疾病进行问卷式调查。对其中256例患者利用酶联吸附试验进行血清总IgE和特异性IgE分析。结果407例过敏性结膜炎中分别有292例(占71.7%)、376例(占92.4%)和115例(占28.2%)同时患有湿疹、鼻炎和哮喘,合并鼻炎者明显高于合并湿疹和哮喘者(P<0.05)。256例血清总IgE和特异性IgE检测中,吸入组230例中有228例(99.1%)总IgE呈阳性,食入组200例中198例(99.0%)总IgE呈阳性;吸入性过敏原以螨和屋尘为主,食入性过敏原以鱼、蟹、虾为主。慢性过敏性结膜炎的过敏原主要是螨、屋尘和鱼,与急性过敏性结膜炎的差异有统计学意义(P<0.05)。而急性过敏性结膜炎的过敏原主要是花粉和蒿草,与慢性过敏性结膜炎差异有统计学意义(P<0.05)。结论儿童过敏性结膜炎常与鼻炎、哮喘及湿疹同时发病,单独发病较少,其中儿童过敏性结膜炎与鼻炎发病尤为密切,故在儿童期联合治疗两种疾病将对防治鼻炎和过敏性结膜炎的发生...

The association between pediatric allergic conjunctivitis and combined disorders

Objective To evaluate the association between aller-gic conjunctivitis and rhinitis,asthma and eczema in children.Methods A retrospective study was conducted on 407 children aged 5 months~17 years from the outpatient clinic at Wuhan Chil-dren's Hospital and Wuhan Union Hospital during the period of Sep.2005~Sep.2006.All cases were diagnosed as allergic conjunc-tivitis by one oculist.Patients were requested to fill out a question-naire about combined rhinitis,asthma,and eczema and a parental history of allergy.Two hundred fifty-six cases were analyzed for total serum IgE and specific IgE levels with ELISA.Results Two hundred ninty-two(71.7%),376(92.4%),115(28.2%)in 407 cases had concomitant eczema,rhinitis and asthma,respectively.Cases with comorbid rhinitis were identified more frequently than those with comorbid asthma and eczema(P <0.05).Two hundred twenty-eight(99.1%)of 230 in the aeroallergen-related group and 198(99.0%)of 200 in the food allergen-related group had total IgE that was positive.The main aeroallergens were house dust mites,house dust and fungi,and the main food allergens were fish,crab and shrimp.Compared to children with chronic allergic conjunctivi-tis,children with acute allergic conjunctivitis had a higher fre-quency of sensitivity to pollen and wormwood grass(P<0.05).Sensi-tivity to house dust mites,house dust and fish was more common in chronic allergic conjunctivitis than in acute allergic conjunctivitis(P >0.05).Conclusion Allergic conjunctivitis has a frequent co-morbidity to allergic rhinitis and to asthma and eczema in child-hood,and is rarely found in isolation.While allergic conjunctivitis is intimately interrelated with rhinitis,suggested guidelines for the co-treatment of the two diseases will provide benefits for the pre-vention and cure of allergic rhinitis and asthma in the future.